Tag | Content |
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CPLM ID | CPLM-014409 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | U1 small nuclear ribonucleoprotein A |
Protein Synonyms/Alias | U1 snRNP A; U1-A; U1A |
Gene Name | Snrpa |
Gene Synonyms/Alias | Rnu1a-1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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26 | YINNLNEKIKKDELK | ubiquitination | [1] | 94 | PMRIQYAKTDSDIIA | ubiquitination | [1] | 102 | TDSDIIAKMKGTYVE | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro (By similarity). |
Sequence Annotation | DOMAIN 16 95 RRM 1. DOMAIN 213 287 RRM 2. MOD_RES 66 66 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 287 AA |
Protein Sequence | MATIATMPVP ETRANHTIYI NNLNEKIKKD ELKKSLYAIF SQFGQILDIL VSRIMKMRGQ 60 AFVIFKEVTS ATNALRSMQG FPFYDKPMRI QYAKTDSDII AKMKGTYVER DRKREKRKPK 120 SQETPAAKKA VQGGAAAPVV GAVQPVPGMP PMPQAPRIMH HMPGQPPYMP PPGMIPPPGL 180 APGQIPPGAM PPQQLMPGQM PPAQPLSENP PNHILFLTNL PEETNELMLS MLFNQFPGFK 240 EVRLVPGRHD IAFVEFDNEV QAGAARDALQ GFKITQNNAM KISFAKK 287 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
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