CPLM-005906

Genbank Nucleotide ID

High mobility group protein B2

Protein Synonyms/Alias

High mobility group protein 2; HMG-2

Mus musculus (Mouse)

Position	Peptide	Type	References
29	TCREEHKKKHPDSSV	acetylation	[1]
30	CREEHKKKHPDSSVN	acetylation	[1, 2]
43	VNFAEFSKKCSERWK	acetylation	[1]
59	MSAKEKSKFEDLAKS	acetylation	[1, 2]
82	MKNYVPPKGDKKGKK	acetylation	[2]
85	YVPPKGDKKGKKKDP	acetylation	[2]
114	SENRPKIKIEHPGLS	acetylation	[1, 2]
128	SIGDTAKKLGEMWSE	acetylation	[1, 2]
128	SIGDTAKKLGEMWSE	succinylation	[2]
147	DKQPYEQKAAKLKEK	acetylation	[2]
154	KAAKLKEKYEKDIAA	acetylation	[1]
154	KAAKLKEKYEKDIAA	ubiquitination	[3]
157	KLKEKYEKDIAAYRA	acetylation	[1, 2, 4]
157	KLKEKYEKDIAAYRA	succinylation	[2]
157	KLKEKYEKDIAAYRA	ubiquitination	[3]

[1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]

Functional Description

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS).

DNA_BIND 9 79 HMG box 1.
DNA_BIND 95 163 HMG box 2.
MOD_RES 30 30 N6-acetyllysine (By similarity).
MOD_RES 35 35 Phosphoserine.

Acetylation; Chromosome; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0000793; C:condensed chromosome; ISS:UniProtKB.
GO:0005615; C:extracellular space; IEA:Compara.
GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO:0043234; C:protein complex; IEA:Compara.
GO:0042056; F:chemoattractant activity; IEA:Compara.
GO:0003684; F:damaged DNA binding; IEA:Compara.
GO:0008301; F:DNA binding, bending; ISS:UniProtKB.
GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
GO:0006288; P:base-excision repair, DNA ligation; ISS:UniProtKB.
GO:0060326; P:cell chemotaxis; IEA:Compara.
GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
GO:0008584; P:male gonad development; IMP:MGI.
GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
GO:0043388; P:positive regulation of DNA binding; IDA:MGI.
GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Compara.
GO:0045654; P:positive regulation of megakaryocyte differentiation; IEA:Compara.
GO:0032075; P:positive regulation of nuclease activity; IEA:Compara.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
GO:0048545; P:response to steroid hormone stimulus; IMP:MGI.
GO:0007289; P:spermatid nucleus differentiation; IMP:MGI.

IPR009071; HMG_box_dom.
IPR017967; HMG_boxA_CS.

PF09011; DUF1898
PF00505; HMG_box

PS00353; HMG_BOX_1
PS50118; HMG_BOX_2