CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002440
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fatty acid-binding protein, liver 
Protein Synonyms/Alias
 Fatty acid-binding protein 1; Liver-type fatty acid-binding protein; L-FABP 
Gene Name
 FABP1 
Gene Synonyms/Alias
 FABPL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
33EELIQKGKDIKGVSEacetylation[1]
46SEIVQNGKHFKFTITacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine.  
Keyword
 3D-structure; Acetylation; Complete proteome; Cytoplasm; Lipid-binding; Polymorphism; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 127 AA 
Protein Sequence
MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF TITAGSKVIQ 60
NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS VTELNGDIIT NTMTLGDIVF 120
KRISKRI 127 
Gene Ontology
 GO:0045179; C:apical cortex; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005782; C:peroxisomal matrix; ISS:UniProtKB.
 GO:0016209; F:antioxidant activity; IDA:UniProtKB.
 GO:0032052; F:bile acid binding; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0005504; F:fatty acid binding; IEA:Compara.
 GO:0005324; F:long-chain fatty acid transporter activity; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:Compara.
 GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.
 GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.
 GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB.
 GO:0050892; P:intestinal absorption; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Compara.
 GO:0051345; P:positive regulation of hydrolase activity; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR012674; Calycin.
 IPR011038; Calycin-like.
 IPR000463; Fatty_acid-bd.
 IPR000566; Lipocln_cytosolic_FA-bd_dom. 
Pfam
 PF00061; Lipocalin 
SMART
  
PROSITE
 PS00214; FABP 
PRINTS
 PR00178; FATTYACIDBP.