CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008748
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LIM/homeobox protein Lhx4 
Protein Synonyms/Alias
 LIM homeobox protein 4 
Gene Name
 Lhx4 
Gene Synonyms/Alias
 Gsh-4; Gsh4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
44ILDKFILKVLDRHWHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. 
Sequence Annotation
 DOMAIN 28 87 LIM zinc-binding 1.
 DOMAIN 88 150 LIM zinc-binding 2.
 DNA_BIND 157 216 Homeobox.  
Keyword
 3D-structure; Complete proteome; DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 390 AA 
Protein Sequence
MMQSAAVPAE GAVKGLPEML GVPMQQIPQC AGCNQHILDK FILKVLDRHW HSSCLKCADC 60
QMQLADRCFS RAGSVYCKED FFKRFGTKCT ACQQGIPPTQ VVRKAQDFVY HLHCFACIIC 120
NRQLATGDEF YLMEDGRLVC KEDYETAKQN DDSEAGAKRP RTTITAKQLE TLKNAYKNSP 180
KPARHVREQL SSETGLDMRV VQVWFQNRRA KEKRLKKDAG RHRWGQFYKS VKRSRGGSKQ 240
EKESSAEDCG VSDSELSFRE DQILSELGHT NRIYGNVGDV TGGQLMNGSF SMDGTGQSYQ 300
DLRDGSPYGI PQSPSSISSL PSHAPLLNGL DYTVDSNLGI IAHAGQGVSQ TLRAMAGGPT 360
SDLSTGSSVG YPDFPTSPAS WLDEMDHPPF 390 
Gene Ontology
 GO:0005622; C:intracellular; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0021526; P:medial motor column neuron differentiation; IGI:MGI.
 GO:0008045; P:motor neuron axon guidance; IGI:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0009887; P:organ morphogenesis; IMP:MGI.
 GO:0001890; P:placenta development; IGI:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR001781; Znf_LIM. 
Pfam
 PF00046; Homeobox
 PF00412; LIM 
SMART
 SM00389; HOX
 SM00132; LIM 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 
PRINTS