UniProt Accession

 ERCC1_HUMAN; P07992; Q7Z7F5; Q96S40 

Genbank Protein ID

 M13194; M26163; M28650; AF001925; AB069681; BT019806; AF512555; AC092309; AC138128; AC138534; AC139353; CH471126; BC008930; BC052813 

Genbank Nucleotide ID

 AAA52394.1; AAA52395.1; AAA35810.1; AAC16253.1; BAB62810.1; AAV38609.1; AAM34796.1; EAW57349.1; AAH08930.1; AAH52813.1 

Protein Name

 DNA excision repair protein ERCC-1 

Protein Synonyms/Alias

  

Gene Name

 ERCC1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
162	GRLQSLGKNFALRVL	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. 

Sequence Annotation

 DNA_BIND 134 156 Potential.
 MOTIF 17 23 Nuclear localization signal (Potential).  

Keyword

 3D-structure; Alternative splicing; Cataract; Complete proteome; DNA damage; DNA repair; DNA-binding; Endonuclease; Hydrolase; Nuclease; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 297 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0000784; C:nuclear chromosome, telomeric region; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0000109; C:nucleotide-excision repair complex; IDA:UniProtKB.
 GO:0003684; F:damaged DNA binding; IDA:UniProtKB.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0051276; P:chromosome organization; IEA:Compara.
 GO:0006302; P:double-strand break repair; IEA:Compara.
 GO:0048568; P:embryonic organ development; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0045190; P:isotype switching; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0006312; P:mitotic recombination; IMP:UniProtKB.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0010259; P:multicellular organismal aging; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0032205; P:negative regulation of telomere maintenance; IMP:UniProtKB.
 GO:0000718; P:nucleotide-excision repair, DNA damage removal; TAS:Reactome.
 GO:0006295; P:nucleotide-excision repair, DNA incision, 3'-to lesion; IMP:UniProtKB.
 GO:0006296; P:nucleotide-excision repair, DNA incision, 5'-to lesion; IMP:UniProtKB.
 GO:0048477; P:oogenesis; IEA:Compara.
 GO:0035166; P:post-embryonic hemopoiesis; IEA:Compara.
 GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IEA:Compara.
 GO:0001302; P:replicative cell aging; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IMP:UniProtKB.
 GO:0009744; P:response to sucrose stimulus; IEA:Compara.
 GO:0010165; P:response to X-ray; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0006949; P:syncytium formation; IEA:Compara.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; TAS:Reactome.
 GO:0009650; P:UV protection; IEA:Compara. 

Interpro

 IPR004579; DNA_repair_Rad10.
 IPR000445; HhH_motif.
 IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
 IPR011335; Restrct_endonuc-II-like.
 IPR010994; RuvA_2-like. 

Pfam

 PF00633; HHH
 PF03834; Rad10 

SMART

 SM00278; HhH1 

PROSITE

  

PRINTS