CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040776
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin-associated protein 2-like 
Protein Synonyms/Alias
  
Gene Name
 UBAP2L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26NQNQTQHKQRPQATAubiquitination[1, 2]
109KKGVSGQKDGGQTESubiquitination[3]
301DLAVLLGKTPSTMENubiquitination[4]
355SMVSMLGKGFGDVGEubiquitination[2]
364FGDVGEAKGGSTTGSubiquitination[2, 3, 4, 5, 6]
431AVHSPFTKRQAFTPSubiquitination[2, 3, 5]
623SISSSPQKDLTQAKNacetylation[7]
875PYSGDLTKFGRGDASubiquitination[1, 2, 3, 4, 5, 6, 8, 9]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [8] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [9] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1078 AA 
Protein Sequence
MMTSVGTNRA RGNWEQPQNQ NQTQHKQRPQ ATAEQIRLAQ MISDHNDADF EEKVKQLIDI 60
TGKNQDECVI ALHDCNGDVN RAINVLLEGN PDTHSWEMVG KKKGVSGQKD GGQTESNEEG 120
KENRDRDRDY SRRRGGPPRR GRGASRGREC MHGALSKPAV VRGQENGLDG TKSGGPSGRG 180
TERGRRGRGR GRGGSGRRGG RFSAQGMGTF NPADYAEPAN TDDNYGNSSG NTWNNTGHFE 240
PDDGTSAWRT ATEEWGTEDW NEDLSETKIF TASNVSSVPL PAENVTITAG QRIDLAVLLG 300
KTPSTMENDS SNLDPSQAPS LAQPLVFSNS KQTAISQPAS GNTFSHHSMV SMLGKGFGDV 360
GEAKGGSTTG SQFLEQFKTA QALAQLAAQH SQSGSTTTSS WDMGSTTQSP SLVQYDLKNP 420
SDSAVHSPFT KRQAFTPSST MMEVFLQEKS PAVATSTAAP PPPSSPLPSK STSAPQMSPG 480
SSDNQSSSPQ PAQQKLKQQK KKASLTSKIP ALAVEMPGSA DISGLNLQFG ALQFGSEPVL 540
SDYESTPTTS ASSSQAPSSL YTSTASESSS TISSNQSQES GYQSGPIQST TYTSQNNAQG 600
PLYEQRSTQT RRYPSSISSS PQKDLTQAKN GFSSVQATQL QTTQSVEGAT GSAVKSDSPS 660
TSSIPPLNET VSAASLLTTT NQHSSSLGGL SHSEEIPNTT TTQHSSTLST QQNTLSSSTS 720
SGRTSTSTLL HTSVESEANL HSSSSTFSTT SSTVSAPPPV VSVSSSLNSG SSLGLSLGSN 780
STVTASTRSS VATTSGKAPP NLPPGVPPLL PNPYIMAPGL LHAYPPQVYG YDDLQMLQTR 840
FPLDYYSIPF PTPTTPLTGR DGSLASNPYS GDLTKFGRGD ASSPAPATTL AQPQQNQTQT 900
HHTTQQTFLN PALPPGYSYT SLPYYTGVPG LPSTFQYGPA VFPVAPTSSK QHGVNVSVNA 960
SATPFQQPSG YGSHGYNTGV SVTSSNTGVP DISGSVYSKT QSFEKQGFHS GTPAASFNLP 1020
SALGSGGPIN PATAAAYPPA PFMHILTPHQ QPHSQILHHH LQQDGQDILN FVDDQLGE 1078 
Gene Ontology
  
Interpro
 IPR022166; DUF3697_Uba2.
 IPR009060; UBA-like.
 IPR015940; UBA/transl_elong_EF1B_N_euk. 
Pfam
 PF12478; DUF3697 
SMART
 SM00165; UBA 
PROSITE
 PS50030; UBA 
PRINTS