UniProt Accession

 Q569X3_MOUSE; Q569X3 

Genbank Protein ID

 BC092266; AK137213; AK168973; CH466606 

Genbank Nucleotide ID

 AAH92266.1; BAE23273.1; BAE40776.1; EDL22551.1 

Protein Name

 U1 small nuclear ribonucleoprotein C 

Protein Synonyms/Alias

 U1 snRNP C; U1-C; U1C 

Gene Name

 Snrpc 

Gene Synonyms/Alias

 Snrp1c; mCG_21696 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
52	QAQSLIDKTTAAFQQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA (By similarity). 

Sequence Annotation

 ZN_FING 4 36 Matrin-type (By similarity).  

Keyword

 Metal-binding; Nucleus; Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 159 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:Compara.
 GO:0000243; C:commitment complex; IEA:HAMAP.
 GO:0005685; C:U1 snRNP; IEA:HAMAP.
 GO:0071004; C:U2-type prespliceosome; IEA:HAMAP.
 GO:0003729; F:mRNA binding; IEA:HAMAP.
 GO:0003727; F:single-stranded RNA binding; IEA:Compara.
 GO:0030619; F:U1 snRNA binding; IEA:HAMAP.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0000395; P:mRNA 5'-splice site recognition; IEA:HAMAP.
 GO:0000387; P:spliceosomal snRNP assembly; IEA:HAMAP. 

Interpro

 IPR017340; U1_snRNP-C.
 IPR000690; Znf_C2H2_matrin.
 IPR003604; Znf_U1.
 IPR013085; Znf_U1-C. 

Pfam

 PF06220; zf-U1 

SMART

 SM00451; ZnF_U1 

PROSITE

 PS50171; ZF_MATRIN 

PRINTS