CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024753
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcriptional regulator sirC 
Protein Synonyms/Alias
  
Gene Name
 sirC 
Gene Synonyms/Alias
 hilC; sprA; SL1344_2847 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain SL1344) 
NCBI Taxa ID
 216597 
Lysine Modification
Position
Peptide
Type
References
208IISDLTRKWSQAEVAacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Positive regulator of the expression of the invasion- associated type III secretion system encoded within SPI-1 (pathogenicity island 1) (By similarity). 
Sequence Annotation
 DNA_BIND 211 229 H-T-H motif (By similarity).  
Keyword
 Activator; Complete proteome; DNA-binding; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 295 AA 
Protein Sequence
MVLPSMNKSV EAISNNHLQQ PNKFPLINGL ADVRDYYVAN CLLFKLNKGS LRIENEFGEF 60
IERSAPCLFL LEKDQTITLS MSEIEGHIDF SSLEVSYDLM QKFYKVFYST RNYNDRELSL 120
KTKPKYFFHA DLLPGMSDTF DSILHGVACP RVCSNVSIDD HDYSYFSLMY LISAFVRKPG 180
GFDFLERAIK ITTKEKVYNI IISDLTRKWS QAEVAGKLFM SVSSLKRKLA AEEVSFSKIY 240
LDARMNQAIK LLRMGAGNIS QVATMCGYDT PSYFIAIFKR HFKITPLSFM RTMNH 295 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR009057; Homeodomain-like.
 IPR018060; HTH_AraC.
 IPR018062; HTH_AraC-typ_CS.
 IPR020449; Tscrpt_reg_HTH_AraC-type. 
Pfam
 PF12833; HTH_18 
SMART
 SM00342; HTH_ARAC 
PROSITE
 PS00041; HTH_ARAC_FAMILY_1
 PS01124; HTH_ARAC_FAMILY_2 
PRINTS
 PR00032; HTHARAC.