CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031354
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Epidermal growth factor receptor kinase substrate 8 
Protein Synonyms/Alias
 Epidermal growth factor receptor pathway substrate 8, isoform CRA_b; cDNA FLJ50272, highly similar to Epidermal growth factor receptor kinase substrate 8; cDNA, FLJ79033, highly similar to Epidermal growth factor receptor kinase substrate 8; cDNA, FLJ79138, highly similar to Epidermal growth factor receptor kinase substrate 8 
Gene Name
 EPS8 
Gene Synonyms/Alias
 hCG_1811074 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
521YSQITVQKAALEDSSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Receptor; Reference proteome; SH3 domain; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 562 AA 
Protein Sequence
MMAARIDRDV QILNHILDDI EFFITKLQKA AEAFSELSKR KKNKKGKRKG PGEGVLTLRA 60
KPPPPDEFLD CFQKFKHGFN LLAKLKSHIQ NPSAADLVHF LFTPLNMVVQ ATGGPELASS 120
VLSPLLNKDT IDFLNYTVNG DERQLWMSLG GTWMKARAEW PKEQFIPPYV PRFRNGWEPP 180
MLNFMGATME QDLYQLAESV ANVAEHQRKQ EIKRLSTEHS SVSEYHPADG YAFSSNIYTR 240
GSHLDQGEAA VAFKPTSNRH IDRNYEPLKT QPKKYAKSKY DFVARNNSEL SVLKDDILEI 300
LDDRKQWWKV RNASGDSGFV PNNILDIVRP PESGLGRADP PYTHTIQKQR MEYGPRPADT 360
PPAPSPPPTP APVPVPLPPS TPAPVPVSKV PANITRQNSS SSDSGGSIVR DSQRHKQLPV 420
DRRKSQMEEV QDELIHRLTI GRSAAQKKFH VPRQNVPVIN ITYDSTPEDV KTWLQSKGFN 480
PVTVNSLGVL NGAQLFSLNK DELRTVCPEG ARVYSQITVQ KAALEDSSGS SELQEIMRRR 540
QEKISAAASD SGVESFDEGS SH 562 
Gene Ontology
 GO:0017146; C:N-methyl-D-aspartate selective glutamate receptor complex; IEA:Compara.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0031532; P:actin cytoskeleton reorganization; IEA:Compara.
 GO:0051017; P:actin filament bundle assembly; IEA:Compara.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0048149; P:behavioral response to ethanol; IEA:Compara. 
Interpro
 IPR001452; SH3_domain. 
Pfam
 PF00018; SH3_1 
SMART
 SM00326; SH3 
PROSITE
 PS50002; SH3 
PRINTS