CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027803
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongation factor Ts, mitochondrial 
Protein Synonyms/Alias
 EF-Ts; EF-TsMt 
Gene Name
 Tsfm 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
132DFVSRNLKFQQLVQQacetylation[1, 2, 3, 4]
132DFVSRNLKFQQLVQQsuccinylation[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Elongation factor; Mitochondrion; Protein biosynthesis; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 193 AA 
Protein Sequence
MSLLRSLRFF PVACTGRSAR AVLLQPSQPW LTFHAGPSLS SAASSKELLM KLRRKTGYSF 60
VNCKKALETC GGDLKQAEDW LHKQAQKEGW SKAAKLHGRK TKEGLIGLLQ EGNTAVLVEV 120
NCETDFVSRN LKFQQLVQQV ALGTMAHCQN LTDRLSTYSK GFLNSSELSE LAAGPDREGS 180
LKDQLALAIG EYL 193 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003746; F:translation elongation factor activity; IEA:HAMAP. 
Interpro
 IPR001816; Transl_elong_EFTs/EF1B.
 IPR014039; Transl_elong_EFTs/EF1B_dimer.
 IPR018101; Transl_elong_Ts_CS.
 IPR009060; UBA-like.
 IPR000449; UBA/transl_elong_EF1B_N. 
Pfam
 PF00889; EF_TS
 PF00627; UBA 
SMART
  
PROSITE
 PS01126; EF_TS_1
 PS01127; EF_TS_2 
PRINTS