CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031863
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein kinase domain-containing protein 
Protein Synonyms/Alias
 Protein kinase domain-containing protein, putative 
Gene Name
 TGGT1_059690, TGME49_101270 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
3274SRGRCLGKEGEKIRTacetylation[1]
3479LAAPFAAKPATQTAPacetylation[1]
Reference
 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907
Functional Description
  
Sequence Annotation
  
Keyword
 Hydrolase; Kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3520 AA 
Protein Sequence
MGGGVGRAPR AGRGASVSDS EALSLPALLP PLSPLSSPSP ALGDSACFPF IGLEPLKPPA 60
GGRGSPASPV RSLSSILIVS SASAAAFVRS ASSSFASSLS SRASSSSAPV PVYIHPVSGT 120
VHPYPAQPAP PPPTHLVLAV PASASYAPPA SSSSSSFLEG LSVGFSGVSG RTSARATAQE 180
KPDASFFAAL QTSVVQLLKR SRSIRSVVLR GDGDWLEVLR EALQNHVSVS SVSLEAVTNL 240
SEKELTSGYA RLLSGLSKCT SISIRGCGLT SRGLKSLLRS LGKQSDFVEH LQEIDLAHND 300
LDDEAAAVLL SLFSSSSPRR LASLRLDANP CSLSALEPLL ALLASCDGAS SEEESGLNLL 360
SLGGLTNSAF LSTLTHLDLS HVPSLLSDDD VALLVEILFP RESLPRLQTR GGRDERGKSP 420
ACTRKPQTAK GRDRSVSAVS SVSSLLSLSL AGDGLTGGCL RALALGLLSP SCRLQHLDLS 480
RNSFGKKPSI DGDAGSDSHA PERKDKDKRR AKGRPGARKR PEEKEEEALP IEPLVDALQQ 540
GYEEAPHAPC GLRFLSLAFC ELSLEAMQQL AAALLTNGEN LVFLDLRGNL RSAEGPDGGE 600
EQRKGDRRDE LRLARCAFDT VAGMCGLQVL LLEEETKKRR QETEETEETE ETQETGRKRQ 660
KRGTRQPKGR RRDKATEEAN EEEGTVEEGE DEEDEEEDDE KHGEEGTRGV RGGRAVEIER 720
RRCGGKGGRG RRSEKSESKK RKAEMAEEDS GRSSVRTRRQ RKDDEEEEEE EEEEEEEEEE 780
EEDDEEEEED DEEDESFDEL DAMEAEQKAD ESSEDEGGED GEEKEEDEEE EEEEDETTRT 840
SLRKRGRHSG MRSEKEQESL SKATEPRQRT MESENGGKTT PRRGRPTRRT SADSSRRKKS 900
KKDESEEEEE EEDEEEEEEE EEEEEDDDDE EYEEGESVTG RKGRRRRHPQ RGRDQVVSAH 960
VRKRRKTTAE EKEAGEERLE KREQVDEQVE ENLKNNAVLP SPSPQKEGRR RRTVCAVPSA 1020
RASRPRKTRA DPEDETSFPE TAGDQESCML SGQTSASPSL PLRSRQKSRW IEEDSVSGPL 1080
PHPRASRPSS FFVAETGRIG VGGAQPRRSC SALMSTTSVD LEGGGELFGN RERGPPRRRQ 1140
SASFLAAPAA PAIVVHQVSP APGAGERPRK KESLAVNKKS EATFSSSVVS AATPVDTPFL 1200
MYFDMKREYP ATSALRDPEA NGDLRPGEED ALPRGGVYVQ PSAGAPSEAR EALGRVRVRE 1260
EEARRVESSR GFAVLPPVPA APEEQRDIRV FLNRAGIHLL NLFFPRDSHS YVGKTPLQPL 1320
LRSYPQELLL GLKYILSSHY LPLLSFPDVY TLQELSLSPH LSPPLQLLLS IIFEELARTN 1380
LTYKYQQYGE LGFDENLCHP GKVLFDGGPG CQAIHAAEFR VFWMRRHGRR LGRRRPGWGS 1440
RAQLAVGSRA DDAPVAPFQS PPPPLPLASP QASGLERERL FSGKKFERRD PRDAFSGACT 1500
LDGLDHDSPP GASPCTSPKQ AEFPPPTPQF VETPDRVRGL AGLFEGSPRS AFSAAENGDH 1560
STSLSTVFDL LEPARLHPLA ASFDGDTFGA AGPEKSLLKI SGKAPENGRP LQCTCGRDEA 1620
ERRRQLPGER PSKPPLREKK PLDAETKKNS ADGSRTADGA PAPELSEVPT GQPPPLPSAE 1680
KSGAELFATP APFRWMKKAL GAVRSQGISG LKKETVPRNL DFYFRLNRRA SDDAAQLQAK 1740
ADSAKRGETS TARAESTGGL NAAGPLAAGE EFQGLSDAGK DETDVASKNR ETPGGGVSRS 1800
SVDSRSLSER RDSEVSVSAP ADDRDSQDEV VAVSRPSALT GRGGLYSAVS SPALSASDFA 1860
EELSENEARP VVLRTNGHRP EVRPAEPRRE EEGDTFGPPA WAPKGEAPGS EEGKATRDDE 1920
EKAGREKAPV PRCASTPQDR FVVSWDDDEW LGSIECFLDD LSLCPSAVST RACSFESSST 1980
HGASCPLASR GAPHTRSLPA DFVLHPPLLP PSLSPSAPPS SVSLSAVSAP LVPASPCVGG 2040
AGVQTPGPCS CREVIVVDVQ SDAQLRKRIW DVQTLFTGSE LSVHRKIELL RRMVLRSIKS 2100
AATGYGEQKD EVKRLAAEHD GFVYLGDVNY GFSRHMALLF KVLCDASQIP CRVMRAGLLG 2160
EETVGDNGDT SARSPELGGG APGEGEKRLA GPRARRDGLE RQERRRREEE EFVYNVVLVK 2220
DATKSELEQL IPIIWTQNAA AGLWRRYLSP GVEKGARGED RERKRGRHSS LTDFLASGVV 2280
RLNPPTLSSI PLPRRLRALQ RRLAVSSASF SSCGQERSSE RSRCVERDLE TETGRGATAG 2340
NERCGDTAGD LGGDRELPPL GRARSPRPFD YFKHGWVDRR RETSHCCCCA SRSLPSLEAE 2400
TGGDRAETRG DNGRDNRVGR DSAPGGDVTS RNESSEKTEK ENWGAKPSED GPLHRQHADL 2460
DRLLLAASGA SAFCGCGGAP ASVAATELDL DAFFDFREKL GKGSFGEVWR VRIKSEGRAV 2520
GAARRKPRER KRSREEQDAG VREENAVSEE EERGKEVHSG EERAEAPWRR ETDEDGEADE 2580
AGERGEADEA CRGDSGEPAE PEYALKLVPK SEENLPEAEI MRSYSHPRVV PFLGVFEGFQ 2640
MLEDRSKKKV KNTSLCFLMD IADQSLESLL EEHEKANTCL DVEFILTILL DTARGMNYLH 2700
SPSATKPHLL HRDLKPANIL LKDGRAMVTD FGVARVAEVS FEHEMTQGPG TEGYIAPEQR 2760
TAAYDRPADV WAFGVVCARL LGLREWKKLS DPQHRVALSD FALKDAFLIN LCLACLERRP 2820
LMRPTFHQIV QRLIDKIFRL EFERILRTPY RNCLPLLHAE NPLVFSSPAS LPVGRGDTPS 2880
RAVETVDVRR LGEKSGAITP FRSPSLCPSQ LAPPARPVPS RLSRSLLEAP FSAGGENVEA 2940
LASRTEKVSP KARPEEGVCS GRPASACTHR SGNDEAAAPA SSLSTGGEEE VFFSGEESEA 3000
TSQAKNAEAK GEPQLGPVAD PEVTEDQEEE GFFSRLRLRT MKRSRPLLLS SSEVSPASSE 3060
REDAAEECDG AVEPDTNAKE KKLETKSESN EKSQEKREEV DPVDGVVTPH RLSPSDKKEP 3120
KEPSLLKKSG VSPLQKKQAS PASKKKVWKT PTSFVSLRTP DKVAANSSSS SSSSSSSSSS 3180
SSSSSSSSSS SASSSPSSPS SAASASLSPT GGSRRRAASP QREREERRRP GRTSPKLTPR 3240
GREEERRLSP TEKDDRGQSL SRGRSVSRGR CLGKEGEKIR TKERNAEKTP TQTPNHRRRS 3300
PSPSLSTSPL SRFDEAGVQD AEEGVLRHPS SRGPRSKISE NPRISACSPS SPFSPCPSPS 3360
SASSPSAFSS LSASVLKNRV GSVDAQRSLG ERKGLLLSSS ASVGSETRDA RRSPEGVSAV 3420
SSEGSASLSG APRVLASRQA DSSSDSLVET EISHAPNCAS SAFPPPARVA GLAAPFAAKP 3480
ATQTAPIRKG DSFSDAYKVS GATEQLASGG NEGRGSGSLS 3520 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004382; F:guanosine-diphosphatase activity; IEA:EC.
 GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR026840; ARMC3/CTR1.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF14381; EDR1
 PF00069; Pkinase 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS