| Tag | Content |
|---|
| CPLM ID | CPLM-020396 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | tRNA pseudouridine(38/39) synthase |
Protein Synonyms/Alias | tRNA pseudouridine synthase 3; tRNA pseudouridylate synthase 3; tRNA-uridine isomerase 3 |
Gene Name | PUS3 |
Gene Synonyms/Alias | FKSG32 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 99 | KLFEALTKTRLVESR | ubiquitination | [1] | | 227 | HDFRNLCKMDVANGV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity). |
Sequence Annotation | ACT_SITE 118 118 Nucleophile (By similarity).
BINDING 195 195 Substrate (By similarity).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 456 456 Phosphothreonine.
MOD_RES 468 468 Phosphothreonine. |
Keyword | Acetylation; Complete proteome; Isomerase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; tRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 481 AA |
Protein Sequence | MAYNDTDRNQ TEKLLKRVRE LEQEVQRLKK EQAKNKEDSN IRENSAGAGK TKRAFDFSAH 60
GRRHVALRIA YMGWGYQGFA SQENTNNTIE EKLFEALTKT RLVESRQTSN YHRCGRTDKG 120
VSAFGQVISL DLRSQFPRGR DSEDFNVKEE ANAAAEEIRY THILNRVLPP DIRILAWAPV 180
EPSFSARFSC LERTYRYFFP RADLDIVTMD YAAQKYVGTH DFRNLCKMDV ANGVINFQRT 240
ILSAQVQLVG QSPGEGRWQE PFQLCQFEVT GQAFLYHQVR CMMAILFLIG QGMEKPEIID 300
ELLNIEKNPQ KPQYSMAVEF PLVLYDCKFE NVKWIYDQEA QEFNITHLQQ LWANHAVKTH 360
MLYSMLQGLD TVPVPCGIGP KMDGMTEWGN VKPSVIKQTS AFVEGVKMRT YKPLMDRPKC 420
QGLESRIQHF VRRGRIEHPH LFHEEETKAK RDCNDTLEEE NTNLETPTKR VCVDTEIKSI 480
I 481 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0009982; F:pseudouridine synthase activity; IEA:Compara. GO:0003723; F:RNA binding; IEA:InterPro. GO:0031119; P:tRNA pseudouridine synthesis; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |