| Tag | Content |
|---|
| CPLM ID | CPLM-017769 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 |
Protein Synonyms/Alias | Multisynthase complex auxiliary component p38; Protein JTV-1 |
Gene Name | Aimp2 |
Gene Synonyms/Alias | Jtv1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 70 | LKRLYELKAAVDGLS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. |
Sequence Annotation | DOMAIN 220 317 GST C-terminal.
REGION 82 162 Interaction with PARK2 (By similarity).
REGION 162 225 Interaction with TP53 (By similarity).
MOD_RES 36 36 Phosphoserine. |
Keyword | Apoptosis; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 320 AA |
Protein Sequence | MPMYQVKPYH GGSAPLHVEL PTCMYRLPNV HSKTTSPATD AGHVQETSEP SLQALESRQD 60
DILKRLYELK AAVDGLSKMI HTPDADLDVT NILQADEPTT LATNTLDLNS VLGKDYGALK 120
DIVINANPAS PPLSLLVLHR LLCERYRVLS TVHTHSSVKN VPENLVKCFG EQARKQSRHE 180
YQLGFTLIWK NVPKTQMKFS VQTMCPIEGE GNIARFLFSL FGQKHNAVTL TLIDSWVDIA 240
MFQLREGSSK EKAAVFRSMN SALGRSPWLV GNELTVADVV LWSVLQQTGG SSGAAPTNVQ 300
RWLKSCENLA PFSTALQLLK 320 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:MGI. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0008285; P:negative regulation of cell proliferation; IDA:MGI. GO:0031398; P:positive regulation of protein ubiquitination; IDA:MGI. GO:0006412; P:translation; IEA:UniProtKB-KW. GO:0060510; P:Type II pneumocyte differentiation; IMP:MGI. |
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Pfam | |
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PRINTS | |