CPLM-001744

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-001744

UniProt Accession

Genbank Protein ID

M31994; M31982; M31983; M31984; M31985; M31986; M31987; M31988; M31989; M31990; M31991; M31992; AF003341; AY390731; BT006921; AY338497; AL591031; CH471089; BC001505; S61235; M26761; K03000

Genbank Nucleotide ID

AAA51692.1; AAA51692.1; AAA51692.1; AAA51692.1; AAA51692.1; AAA51692.1; AAA51692.1; AAA51692.1; AAA51692.1; AAA51692.1; AAA51692.1; AAA51692.1; AAC51652.1; AAR92229.1; AAP35567.1; AAP88039.1; CAI12257.1; EAW62543.1; AAH01505.1; AAD13925.1; AAA35518.1; AAA51695.1

Protein Name

Retinal dehydrogenase 1

Protein Synonyms/Alias

RALDH 1; RalDH1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic

Gene Name

ALDH1A1

Gene Synonyms/Alias

ALDC; ALDH1; PUMB1

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
91	ERGRLLYKLADLIER	acetylation	[1]
128	NDLAGCIKTLRYCAG	acetylation	[1]
252	TGSTEVGKLIKEAAG	acetylation	[1]
353	IDKEQYDKILDLIES	acetylation	[1]
367	SGKKEGAKLECGGGP	acetylation	[1]
410	GPVQQIMKFKSLDDV	acetylation	[1]
419	KSLDDVIKRANNTFY	acetylation	[1]
435	LSAGVFTKDIDKAIT	acetylation	[1]
495	EVKTVTVKISQKNS*	acetylation	[1]

Reference

[1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]

Functional Description

Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).

Sequence Annotation

NP_BIND 246 251 NAD (By similarity).
ACT_SITE 269 269 Proton acceptor.
ACT_SITE 303 303 Nucleophile.
BINDING 456 456 NAD.
MOD_RES 2 2 N-acetylserine.
MOD_RES 91 91 N6-acetyllysine.
MOD_RES 128 128 N6-acetyllysine.
MOD_RES 252 252 N6-acetyllysine.
MOD_RES 353 353 N6-acetyllysine.
MOD_RES 367 367 N6-acetyllysine.
MOD_RES 410 410 N6-acetyllysine.
MOD_RES 419 419 N6-acetyllysine.
MOD_RES 435 435 N6-acetyllysine.
MOD_RES 495 495 N6-acetyllysine.

Keyword

Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

501 AA

Protein Sequence

MSSSGTPDLP VLLTDLKIQY TKIFINNEWH DSVSGKKFPV FNPATEEELC QVEEGDKEDV 60
DKAVKAARQA FQIGSPWRTM DASERGRLLY KLADLIERDR LLLATMESMN GGKLYSNAYL 120
NDLAGCIKTL RYCAGWADKI QGRTIPIDGN FFTYTRHEPI GVCGQIIPWN FPLVMLIWKI 180
GPALSCGNTV VVKPAEQTPL TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDID 240
KVAFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVLA DADLDNAVEF AHHGVFYHQG 300
QCCIAASRIF VEESIYDEFV RRSVERAKKY ILGNPLTPGV TQGPQIDKEQ YDKILDLIES 360
GKKEGAKLEC GGGPWGNKGY FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSLDDVIKR 420
ANNTFYGLSA GVFTKDIDKA ITISSALQAG TVWVNCYGVV SAQCPFGGFK MSGNGRELGE 480
YGFHEYTEVK TVTVKISQKN S 501

Gene Ontology

GO:0005829; C:cytosol; TAS:Reactome.
GO:0004029; F:aldehyde dehydrogenase (NAD) activity; EXP:Reactome.
GO:0005497; F:androgen binding; TAS:ProtInc.
GO:0005099; F:Ras GTPase activator activity; TAS:UniProtKB.
GO:0001758; F:retinal dehydrogenase activity; IEA:EC.
GO:0006081; P:cellular aldehyde metabolic process; TAS:ProtInc.
GO:0006069; P:ethanol oxidation; TAS:Reactome.
GO:0042572; P:retinol metabolic process; IEA:UniProtKB-UniPathway.
GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.

Interpro

IPR016161; Ald_DH/histidinol_DH.
IPR016163; Ald_DH_C.
IPR016160; Ald_DH_CS.
IPR016162; Ald_DH_N.
IPR015590; Aldehyde_DH_dom.

Pfam

PF00171; Aldedh

SMART

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS
PS00687; ALDEHYDE_DEHYDR_GLU

PRINTS