| Tag | Content |
|---|
| CPLM ID | CPLM-007146 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-dependent RNA helicase DHH1 |
Protein Synonyms/Alias | DExD/H-box helicase 1 |
Gene Name | DHH1 |
Gene Synonyms/Alias | YDL160C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 324 | MKQQERNKVFHEFRQ | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export. Required for sporulation. |
Sequence Annotation | DOMAIN 77 247 Helicase ATP-binding.
DOMAIN 257 417 Helicase C-terminal.
NP_BIND 90 97 ATP (By similarity).
MOTIF 46 74 Q motif.
MOTIF 195 198 DEAD box. |
Keyword | 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase; mRNA processing; mRNA transport; Nucleotide-binding; Reference proteome; RNA-binding; Translation regulation; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 506 AA |
Protein Sequence | MGSINNNFNT NNNSNTDLDR DWKTALNIPK KDTRPQTDDV LNTKGNTFED FYLKRELLMG 60
IFEAGFEKPS PIQEEAIPVA ITGRDILARA KNGTGKTAAF VIPTLEKVKP KLNKIQALIM 120
VPTRELALQT SQVVRTLGKH CGISCMVTTG GTNLRDDILR LNETVHILVG TPGRVLDLAS 180
RKVADLSDCS LFIMDEADKM LSRDFKTIIE QILSFLPPTH QSLLFSATFP LTVKEFMVKH 240
LHKPYEINLM EELTLKGITQ YYAFVEERQK LHCLNTLFSK LQINQAIIFC NSTNRVELLA 300
KKITDLGYSC YYSHARMKQQ ERNKVFHEFR QGKVRTLVCS DLLTRGIDIQ AVNVVINFDF 360
PKTAETYLHR IGRSGRFGHL GLAINLINWN DRFNLYKIEQ ELGTEIAAIP ATIDKSLYVA 420
ENDETVPVPF PIEQQSYHQQ AIPQQQLPSQ QQFAIPPQQH HPQFMVPPSH QQQQAYPPPQ 480
MPSQQGYPPQ QEHFMAMPPG QSQPQY 506 |
Gene Ontology | GO:0000932; C:cytoplasmic mRNA processing body; IDA:SGD. GO:0010494; C:cytoplasmic stress granule; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004004; F:ATP-dependent RNA helicase activity; ISS:SGD. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:SGD. GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IMP:SGD. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. GO:0034063; P:stress granule assembly; IMP:SGD. |
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