CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019953
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock 70 kDa protein 14 
Protein Synonyms/Alias
 NST-1; hsr.1 
Gene Name
 Hspa14 
Gene Synonyms/Alias
 Hsp70-4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
331FTADDINKVVLCGGSubiquitination[1]
343GGSSRIPKLQQLIKDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 509 AA 
Protein Sequence
MAAIGVHLGC TSACVAVYKD GRADVVANDA GDRVTPAIVA YSEREQVVGL AAKQSRIRHV 60
SSTVVKVKQI LGRSSADPQA QKYISESKCL VIEKNGKLRY EIDTGEETKL VNPEDVARLI 120
FSKMKETAHS VLGSDANDVV VTVPFDFGEK QKSALGEAAG AAGFNVLRLI HEPSAALLAY 180
GIGQDHPTGK SNVLVFKLGG TSLSLSVMEV NSGMYRVLST NTSDNIGGAH FTDTLAQYLA 240
SEFQRLFKHD VRGNARAMMK LMNSAEVAKH SLSTLGSANC FVDSLYEGQD FDCNVSRARF 300
ELLCSPLFNK CTEAIRELLR QTGFTADDIN KVVLCGGSSR IPKLQQLIKD LFPAVDLLNS 360
IPPDEVIPIG AAIEAGILVG KESTSGDDSV MIECSAKDIL VKGVDESGAD RFTVLFPSGT 420
PLPARRQHTL QAPGRVSSVC LELYESEGKN SAKEEAKFAQ VVLQDLDKKE NGLRDILAVL 480
TMKRDGSLQV TCTDQDTGKC EAITVEVAS 509 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005840; C:ribosome; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.