UniProt Accession

 TRX3_YEAST; P25372; D6VR84 

Genbank Protein ID

 X59720; BK006937 

Genbank Nucleotide ID

 CAA42258.1; DAA07553.1 

Protein Name

 Thioredoxin-3, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 TRX3 

Gene Synonyms/Alias

 YCR083W; YCR83W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
67	MMQPHLTKLIQAYPD	acetylation	[1]
122	ANPTALEKGIKDL**	acetylation	[1]
122	ANPTALEKGIKDL**	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

  

Sequence Annotation

 DOMAIN 22 127 Thioredoxin.
 ACT_SITE 55 55 Nucleophile (By similarity).
 ACT_SITE 58 58 Nucleophile (By similarity).
 DISULFID 55 58 Redox-active (By similarity).  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Electron transport; Mitochondrion; Redox-active center; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0015036; F:disulfide oxidoreductase activity; IDA:SGD.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0034599; P:cellular response to oxidative stress; IMP:SGD.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro. 

Interpro

 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.