CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023169
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIF26A 
Protein Synonyms/Alias
  
Gene Name
 KIF26A 
Gene Synonyms/Alias
 KIAA1236 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
273AGPDGLSKAWGRGGVubiquitination[1]
312FFIRAMQKLSLASKRubiquitination[1]
320LSLASKRKKPHPPPPubiquitination[1]
321SLASKRKKPHPPPPPubiquitination[1]
395AEAMSFLKVDPRKKQubiquitination[1]
575LRAPTAEKAAFYLDAubiquitination[1]
1557RGTVMGTKQALRAAHubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). 
Sequence Annotation
 DOMAIN 368 661 Kinesin-motor.
 NP_BIND 469 476 ATP (Potential).  
Keyword
 ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Motor protein; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1882 AA 
Protein Sequence
MVGRGVPLCA AQPAVAEGGP AREPPPLLEV SPRKRLPAGP DQDPCGSRPA PEGAGAGPEQ 60
GHSAGGGGWC RHCHTKLVEL KRQAWKLVSG PGTTLRDPCL SALLLDKLPA PGALPACRPE 120
AERRCDVCAT HLQQLTREAM HLLQAPASHE DLDAPHGGPS LAPPSTTTSS RDTPGPAGPA 180
GRQPGRAGPD RTKGLAWSPG PSVQVSVAPA GLGGALSTVT IQAQQCLEGM WSVSRVNSFL 240
PPACLAEAAV AAVAVADTVR ECPPVAGPDG LSKAWGRGGV CTSALVTPTP GSVGGSTGPS 300
AAASFFIRAM QKLSLASKRK KPHPPPPPAT RGTSTYPTDF SGVLQLWPPP APPCLLRAAS 360
KTKDNPGSIG KVKVMLRIWP AQGAQRSAEA MSFLKVDPRK KQVILYDPAA GPPGSAGPRR 420
AATAAVPKMF AFDAVFPQDS EQAEVCSGTV ADVLQSVVSG ADGCIFSFGH MSLGKSYTMI 480
GKDSSPQSLG IVPCAISWLF RLIEERRERT GTRFSVRVSA VEVCGRDQSL RDLLAEVAPG 540
SLQDTQSPGV YLREDPVCGA QLQNQSELRA PTAEKAAFYL DAALAARSTS RAGCGEDARR 600
SSHMLFTLHV YQYRMEKCGR GGMSGGRSRL HLIDLGSCEA AAGRAGEAAG GPLCLSLSAL 660
GSVILALVNG AKHVPYRDHR LTMLLRESLA TAGCRTTMIA HVSDAPAQHA ETLSTVQLAA 720
RIHRLRRKKA KYASSSSGGE SSCEEGRARR PPHLRPFHPR TVALDPDRTP PCLPGDPDYS 780
SSSEQSCDTV IYVGPGGAAL SDRELTDNEG PPDFVPIIPA LSRHRPSKGP RDADHFRCST 840
FAELQERLEC MDGNEGPSGG PGGTDGAQAS PARGGRKPSP PEAASPRKAV GTPMAASTPR 900
GSSGPDTHQG TPEPCKAIVW GDQREDSSAW PELLVPEKAA VSGGRRPLPS PAPPPPQLLE 960
ACRAPEEPGG GGTDGVARTP PVGMSGQVAG SPMLPGATCP RLAAGSRCPE RGLLTTTVTL 1020
QRPVELNGED ELVFTVVEEL SLGALAGAGR PTSLASFDSD CSLRALASGS RPVSIISSIN 1080
DEFDAYTSQA PEGGPLEGAA WAGSSHGSSI SSWLSEVSVC TADSRDPTPQ PRFSPDSLAG 1140
LDPGGPPALD GSLGDGSSGF LGPDRPDSPG PTWGPCPGEV AAVAPSRPGR EPQAGPSRWA 1200
SAAQTIHSSL PRKPRTASAT TRVGCARLGQ SPPGRGGLFE DPWLLRVGEC DTQAASAGRA 1260
PSPTLGSPRL PEAQVMLACA QRVVDGCEVA ARAARRPEAV ARIPPLRRGA TTLGVTTPAV 1320
SWGDAPTEVV ACSGSLKASP TSKKGLAPKA GFLPRPSGAA PPAPPTRKSS LEQRSSPASA 1380
PPHAVNPARV GAAAVLRGEE EPRPSSRADH SVPRATSSLK ARASKVEAAH RLAGHASLER 1440
YEGLAHSSSK GREAPGRPPR AVPKLGVPPS SPTHGPAPAC RSGAAKAVGA PKPPVGGGKG 1500
RGLVAGGSRA LGPSVKLSTA SVTGRSPGGP VAGPRAAPRA GPSVGAKAGR GTVMGTKQAL 1560
RAAHSRVHEL SASGAPGRGG SSWGSADSDS GHDSGVNVGE ERPPTGPALP SPYSKVTAPR 1620
RPQRYSSGHG SDNSSVLSGE LPPAMGRTAL FHHSGGSSGY ESLRRDSEAT GSASSAPDSM 1680
SESGAASPGA RTRSLKSPKK RATGLQRRRL IPAPLPDTTA LGRKPSLPGQ WVDLPPPLAG 1740
SLKEPFEIKV YEIDDVERLQ RPRPTPREAP TQGLACVSTR LRLAERRQQR LREVQAKHKH 1800
LCEELAETQG RLMLEPGRWL EQFEVDPELE PESAEYLAAL ERATAALEQC VNLCKAHVMM 1860
VTCFDISVAA SAAIPGPQEV DV 1882 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008017; F:microtubule binding; ISS:UniProtKB.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0048484; P:enteric nervous system development; ISS:UniProtKB.
 GO:0007018; P:microtubule-based movement; TAS:Reactome.
 GO:0009968; P:negative regulation of signal transduction; ISS:UniProtKB.
 GO:0001560; P:regulation of cell growth by extracellular stimulus; ISS:UniProtKB. 
Interpro
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.