UniProt Accession

 PEX19_MOUSE; Q8VCI5; Q4FJU7; Q8CEE1; Q921H0; Q9CZC1; Q9QUQ1 

Genbank Protein ID

 Y09046; Y09047; AK012785; AK028449; AK029368; CT010305; BC012517; BC019767 

Genbank Nucleotide ID

 CAA70255.1; CAA70256.1; BAB28468.1; BAC25957.1; BAC26421.1; CAJ18513.1; AAH12517.1; AAH19767.1 

Protein Name

 Peroxisomal biogenesis factor 19 

Protein Synonyms/Alias

 Peroxin-19; Peroxisomal farnesylated protein; PxF 

Gene Name

 Pex19 

Gene Synonyms/Alias

 Pxf 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
52	PDASGPQKRAPGDTA	ubiquitination	[1]
60	RAPGDTAKDALFASQ	ubiquitination	[1]
92	AEFEKAMKELAEEEP	ubiquitination	[1]
107	HLVEQFQKLSEAAGR	ubiquitination	[1]
130	QEFTSCLKETLSGLA	ubiquitination	[1]
138	ETLSGLAKNATELQN	ubiquitination	[1]
198	SLKEITEKYPEWLQS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity). 

Sequence Annotation

 REGION 1 91 Necessary for PEX19 function on
 REGION 1 56 Docking to the peroxisome membrane and
 MOD_RES 296 296 Cysteine methyl ester (By similarity).
 LIPID 296 296 S-farnesyl cysteine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Lipoprotein; Membrane; Methylation; Peroxisome; Peroxisome biogenesis; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0036105; F:peroxisome membrane class-1 targeting sequence binding; IEA:Compara.
 GO:0061077; P:chaperone-mediated protein folding; IEA:Compara.
 GO:0072321; P:chaperone-mediated protein transport; IEA:Compara.
 GO:1900131; P:negative regulation of lipid binding; IEA:Compara.
 GO:0016559; P:peroxisome fission; IEA:Compara.
 GO:0016557; P:peroxisome membrane biogenesis; IEA:Compara.
 GO:0045046; P:protein import into peroxisome membrane; IEA:Compara.
 GO:0050821; P:protein stabilization; IEA:Compara. 

Interpro

 IPR006708; Pex19. 

Pfam

 PF04614; Pex19 

SMART

  

PROSITE

  

PRINTS