UniProt Accession

 FCY1_YEAST; Q12178; D6W467 

Genbank Protein ID

 U55193; AF005261; Z71255; Z49219; BK006949 

Genbank Nucleotide ID

 AAC13409.1; AAB67713.1; CAA95006.1; CAA89179.1; DAA11483.1 

Protein Name

 Cytosine deaminase 

Protein Synonyms/Alias

 Cytosine aminohydrolase 

Gene Name

 FCY1 

Gene Synonyms/Alias

 YPR062W; YP9499.17 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
27	EEAALGYKEGGVPIG	ubiquitination	[1, 2]
41	GGCLINNKDGSVLGR	ubiquitination	[2]
56	GHNMRFQKGSATLHG	ubiquitination	[2]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4. 

Sequence Annotation

 ACT_SITE 64 64 Proton donor.
 METAL 62 62 Zinc; catalytic.
 METAL 91 91 Zinc; catalytic.
 METAL 94 94 Zinc; catalytic.
 BINDING 51 51 Substrate.
 BINDING 155 155 Substrate.  

Keyword

 3D-structure; Complete proteome; Hydrolase; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 158 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004131; F:cytosine deaminase activity; IDA:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0046087; P:cytidine metabolic process; IMP:SGD.
 GO:0019858; P:cytosine metabolic process; IMP:SGD.
 GO:0008655; P:pyrimidine-containing compound salvage; IMP:SGD.
 GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway. 

Interpro

 IPR016192; APOBEC/CMP_deaminase_Zn-bd.
 IPR002125; CMP_dCMP_Zn-bd.
 IPR016193; Cytidine_deaminase-like. 

Pfam

 PF00383; dCMP_cyt_deam_1 

SMART

  

PROSITE

 PS00903; CYT_DCMP_DEAMINASES 

PRINTS