CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014553
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-glucuronosyltransferase 1-1 
Protein Synonyms/Alias
 UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UDP-glucuronosyltransferase 1A1; UGTBR1 
Gene Name
 Ugt1a1 
Gene Synonyms/Alias
 Ugt1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
80GSFYTLRKFPVPFQKubiquitination[1]
87KFPVPFQKENVTATLubiquitination[1]
439VINNKSYKENIMRLSacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 
Sequence Annotation
 CARBOHYD 89 89 N-linked (GlcNAc...) (Potential).
 CARBOHYD 297 297 N-linked (GlcNAc...) (Potential).
 CARBOHYD 435 435 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane; Microsome; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 535 AA 
Protein Sequence
MTVVCWSSRL LLLLPYLLLC VFGPSASHAG RLLVFPMDGS HWLSMLGVIQ QLQQKGHEVV 60
VIAPEASIHI KEGSFYTLRK FPVPFQKENV TATLVELGRT AFNQDSFLLR VVKIYMKVKR 120
DSSMLLAGCS HLLHNAEFMA SLEESHFDAL LTDPFLPCGS IVAQYLTVPT VYFLNKLPCS 180
LDSEATQCPV PLSYVPKSLS FNSDRMNFLQ RVKNVLLAVS ENFMCRVVYS PYGSLATEIL 240
QKEVTVQDLL SPASIWLMRS DFVKDYPRPI MPNMVFIGGI NCLQKKPLSQ EFEAYVNASG 300
EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN TILVKWLPQN 360
DLLGHPKTRA FITHSGSHGI YEGICNGVPM VMMPLFGDQM DNAKRMETRG AGVTLNVLEM 420
TADDLENALK TVINNKSYKE NIMRLSSLHK DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA 480
HDLTWYQYHS LDVIGFLLAI VLTVVFIVFK CCAYGCRKCF GGKGRVKKSH KSKTH 535 
Gene Ontology
 GO:0070069; C:cytochrome complex; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IDA:MGI.
 GO:0004857; F:enzyme inhibitor activity; IEA:Compara.
 GO:0015020; F:glucuronosyltransferase activity; ISA:MGI.
 GO:0001972; F:retinoic acid binding; IEA:Compara.
 GO:0005496; F:steroid binding; IEA:Compara.
 GO:0006953; P:acute-phase response; IEA:Compara.
 GO:0070980; P:biphenyl catabolic process; IEA:Compara.
 GO:0071361; P:cellular response to ethanol; IEA:Compara.
 GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Compara.
 GO:0051552; P:flavone metabolic process; IEA:Compara.
 GO:0052696; P:flavonoid glucuronidation; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0042594; P:response to starvation; IEA:Compara.
 GO:0052697; P:xenobiotic glucuronidation; IEA:Compara. 
Interpro
 IPR002213; UDP_glucos_trans. 
Pfam
 PF00201; UDPGT 
SMART
  
PROSITE
 PS00375; UDPGT 
PRINTS