CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034334
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cyclin-dependent kinase 1 
Protein Synonyms/Alias
  
Gene Name
 Cdk1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
6**MEDYIKIEKIGEGacetylation[1]
9EDYIKIEKIGEGTYGacetylation[1, 2, 3]
20GTYGVVYKGRHRVTGacetylation[3]
33TGQIVAMKKIRLESEacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 200 AA 
Protein Sequence
MEDYIKIEKI GEGTYGVVYK GRHRVTGQIV AMKKIRLESE EEGVPSTAIR EISLLKELRH 60
PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQFM DSSLVKSYLH QILQGIVFCH 120
SRRVLHRDLK PQNLLIDDKG TIKLADFGLA RAFGIPIRVY THEVVTLWYR SPEVLLGSAR 180
YSTPVDIWSI GTIFAELATK 200 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0005634; C:nucleus; ISO:MGI.
 GO:0005876; C:spindle microtubule; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:Compara.
 GO:0035173; F:histone kinase activity; IEA:Compara.
 GO:0016301; F:kinase activity; IDA:MGI.
 GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:Compara.
 GO:0007569; P:cell aging; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0030261; P:chromosome condensation; IEA:Compara.
 GO:0000278; P:mitotic cell cycle; IEA:Compara.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Compara.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0006461; P:protein complex assembly; IEA:Compara.
 GO:0034501; P:protein localization to kinetochore; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IDA:MGI.
 GO:0014823; P:response to activity; IEA:Compara.
 GO:0014075; P:response to amine stimulus; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0046688; P:response to copper ion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0055015; P:ventricular cardiac muscle cell development; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS