| Tag | Content |
|---|
| CPLM ID | CPLM-019360 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kin of IRRE-like protein 1 |
Protein Synonyms/Alias | Kin of irregular chiasm-like protein 1; Nephrin-like protein 1 |
Gene Name | KIRREL |
Gene Synonyms/Alias | KIRREL1; NEPH1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 729 | EAYDPIGKYATATRF | ubiquitination | [1, 2] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI. J Proteome Res. 2012 Feb 3;11(2):796-807. [ PMID: 22053931] |
Functional Description | Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). |
Sequence Annotation | DOMAIN 21 115 Ig-like C2-type 1.
DOMAIN 120 216 Ig-like C2-type 2.
DOMAIN 223 299 Ig-like C2-type 3.
DOMAIN 308 387 Ig-like C2-type 4.
DOMAIN 392 488 Ig-like C2-type 5.
MOTIF 405 407 Cell attachment site (Potential).
MOD_RES 605 605 Phosphotyrosine; by FYN (By similarity).
MOD_RES 606 606 Phosphotyrosine; by FYN (By similarity).
MOD_RES 622 622 Phosphotyrosine.
MOD_RES 625 625 Phosphotyrosine.
MOD_RES 724 724 Phosphotyrosine.
CARBOHYD 46 46 N-linked (GlcNAc...) (Potential).
CARBOHYD 140 140 N-linked (GlcNAc...) (Potential).
CARBOHYD 297 297 N-linked (GlcNAc...).
CARBOHYD 471 471 N-linked (GlcNAc...) (Potential).
DISULFID 42 100 By similarity.
DISULFID 143 200 By similarity.
DISULFID 244 287 By similarity.
DISULFID 329 371 By similarity.
DISULFID 413 472 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 757 AA |
Protein Sequence | MLSLLVWILT LSDTFSQGTQ TRFSQEPADQ TVVAGQRAVL PCVLLNYSGI VQWTKDGLAL 60
GMGQGLKAWP RYRVVGSADA GQYNLEITDA ELSDDASYEC QATEAALRSR RAKLTVLIPP 120
EDTRIDGGPV ILLQAGTPHN LTCRAFNAKP AATIIWFRDG TQQEGAVAST ELLKDGKRET 180
TVSQLLINPT DLDIGRVFTC RSMNEAIPSG KETSIELDVH HPPTVTLSIE PQTVQEGERV 240
VFTCQATANP EILGYRWAKG GFLIEDAHES RYETNVDYSF FTEPVSCEVH NKVGSTNVST 300
LVNVHFAPRI VVDPKPTTTD IGSDVTLTCV WVGNPPLTLT WTKKDSNMVL SNSNQLLLKS 360
VTQADAGTYT CRAIVPRIGV AEREVPLYVN GPPIISSEAV QYAVRGDGGK VECFIGSTPP 420
PDRIAWAWKE NFLEVGTLER YTVERTNSGS GVLSTLTINN VMEADFQTHY NCTAWNSFGP 480
GTAIIQLEER EVLPVGIIAG ATIGASILLI FFFIALVFFL YRRRKGSRKD VTLRKLDIKV 540
ETVNREPLTM HSDREDDTAS VSTATRVMKA IYSSFKDDVD LKQDLRCDTI DTREEYEMKD 600
PTNGYYNVRA HEDRPSSRAV LYADYRAPGP ARFDGRPSSR LSHSSGYAQL NTYSRGPASD 660
YGPEPTPPGP AAPAGTDTTS QLSYENYEKF NSHPFPGAAG YPTYRLGYPQ APPSGLERTP 720
YEAYDPIGKY ATATRFSYTS QHSDYGQRFQ QRMQTHV 757 |
Gene Ontology | GO:0005911; C:cell-cell junction; IDA:UniProtKB. GO:0043198; C:dendritic shaft; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB. GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0016337; P:cell-cell adhesion; IEA:Compara. GO:0007588; P:excretion; IEA:Compara. GO:0001933; P:negative regulation of protein phosphorylation; IEA:Compara. GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |