CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019933
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family F member 2 
Protein Synonyms/Alias
  
Gene Name
 Abcf2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MPSDLAKKKAAKKKacetylation[1]
8MPSDLAKKKAAKKKEacetylation[1]
208LEELDADKAEMRASRubiquitination[2]
232AMQRKKLKDFSGGWRubiquitination[2]
309HMHNKKLKYYTGNYDacetylation[3]
320GNYDQYVKTRLELEEubiquitination[2]
384TERVVSDKTLSFYFPubiquitination[2]
409MVQNVSFKYTKDGPCacetylation[4]
441VGPNGAGKSTLLKLLubiquitination[2]
613YKEHLKSKLVDEEPQacetylation[4]
623DEEPQLTKRTHNV**ubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
 DOMAIN 91 330 ABC transporter 1.
 DOMAIN 401 618 ABC transporter 2.
 NP_BIND 123 130 ATP 1 (By similarity).
 NP_BIND 435 442 ATP 2 (By similarity).
 MOD_RES 309 309 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 628 AA 
Protein Sequence
MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDAVTEPQVA EEKIEEANGR ETTGDGEVDL 60
LTKELEDFEM KKAAARAVTG VLASHPNSTD VHIINLSLTF HGQELLSDTK LELNSGRRYG 120
LIGLNGIGKS MLLSAIGKRE VPIPEHIDIY HLTREMPPSE KTPLQCVMEV DTERAMLERE 180
AERLAHEDAE CEKLMELYER LEELDADKAE MRASRILHGL GFTPAMQRKK LKDFSGGWRM 240
RVALARALFI RPFMLLLDEP TNHLDLDACV WLEEELKTFK RILVLVSHSQ DFLNGVCTNI 300
IHMHNKKLKY YTGNYDQYVK TRLELEENQM KRFHWEQDQI AHMKNYIARF GHGSAKLARQ 360
AQSKEKTLQK MMASGLTERV VSDKTLSFYF PPCGKIPPPV IMVQNVSFKY TKDGPCIYNN 420
LEFGIDLDTR VALVGPNGAG KSTLLKLLTG ELLPTDGMIR KHSHVKIGRY HQHLQEQLDL 480
DLSPLEYMMK CYPEIKEKEE MRKIIGRYGL TGKQQVSPIR NLSDGQKCRV CLAWLAWQNP 540
HMLFLDEPTN HLDIETIDAL ADAINEFEGG MMLVSHDFRL IQQVAQEIWV CEKQTITKWP 600
GDILAYKEHL KSKLVDEEPQ LTKRTHNV 628 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS