CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007744
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cofilin/actin-depolymerizing factor homolog 
Protein Synonyms/Alias
 Protein D61; Protein twinstar 
Gene Name
 tsr 
Gene Synonyms/Alias
 Cadf; CG4254 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
19KTTYEEIKKDKKHRYacetylation[1]
35IFYIRDEKQIDVETVacetylation[1]
115SSSFDALKKSLVGVQacetylation[1]
123KSLVGVQKYIQATDLacetylation[1]
141SREAVEEKLRATDRQacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
 DOMAIN 4 143 ADF-H.
 MOTIF 19 23 Nuclear localization signal (Potential).  
Keyword
 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 148 AA 
Protein Sequence
MASGVTVSDV CKTTYEEIKK DKKHRYVIFY IRDEKQIDVE TVADRNAEYD QFLEDIQKCG 60
PGECRYGLFD FEYMHQCQGT SESSKKQKLF LMSWCPDTAK VKKKMLYSSS FDALKKSLVG 120
VQKYIQATDL SEASREAVEE KLRATDRQ 148 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0003779; F:actin binding; IMP:FlyBase.
 GO:0030042; P:actin filament depolymerization; IEA:InterPro.
 GO:0030041; P:actin filament polymerization; IMP:FlyBase.
 GO:0007409; P:axonogenesis; IMP:FlyBase.
 GO:0007298; P:border follicle cell migration; IMP:FlyBase.
 GO:0000915; P:cytokinesis, actomyosin contractile ring assembly; TAS:FlyBase.
 GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IMP:FlyBase.
 GO:0042067; P:establishment of ommatidial planar polarity; IMP:FlyBase.
 GO:0008585; P:female gonad development; IMP:FlyBase.
 GO:0036011; P:imaginal disc-derived leg segmentation; IMP:FlyBase.
 GO:0016319; P:mushroom body development; IMP:FlyBase.
 GO:0010591; P:regulation of lamellipodium assembly; IMP:FlyBase.
 GO:0042052; P:rhabdomere development; IMP:FlyBase. 
Interpro
 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR017904; ADF/Cofilin/Destrin. 
Pfam
 PF00241; Cofilin_ADF 
SMART
 SM00102; ADF 
PROSITE
 PS51263; ADF_H 
PRINTS