UniProt Accession

 SUGT1_MOUSE; Q9CX34; Q3UF88; Q9CRE7; Q9D8M6 

Genbank Protein ID

 AK007881; AK020433; AK045153; AK082328; AK141416; AK148838; BC009167 

Genbank Nucleotide ID

 BAB25326.1; BAB32098.1; BAC32241.1; BAC38466.1; BAE24677.1; BAE28673.1; AAH09167.1 

Protein Name

 Suppressor of G2 allele of SKP1 homolog 

Protein Synonyms/Alias

  

Gene Name

 Sugt1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
93	GICEYHEKDYASALE	acetylation	[1]
192	AGEDYSLKLRLLHPI	acetylation	[1]
207	IPEQSTFKVLSTKIE	acetylation	[1]
227	PEAVRWEKLEGQGDE	acetylation	[1]
273	KEEEKNEKLEGDAAL	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. 

Sequence Annotation

 REPEAT 11 44 TPR 1.
 REPEAT 45 78 TPR 2.
 REPEAT 79 112 TPR 3.
 DOMAIN 140 229 CS.
 DOMAIN 247 336 SGS.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 236 236 Phosphothreonine (By similarity).
 MOD_RES 252 252 Phosphoserine (By similarity).
 MOD_RES 302 302 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 336 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 

Interpro

 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR008978; HSP20-like_chaperone.
 IPR007699; SGS.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 

Pfam

 PF04969; CS
 PF05002; SGS
 PF07719; TPR_2 

SMART

  

PROSITE

 PS51203; CS
 PS51048; SGS
 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS