| Tag | Content |
|---|
| CPLM ID | CPLM-007983 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | mRNA decay factor CTH1 |
Protein Synonyms/Alias | Cysteine-three-histidine protein 1 |
Gene Name | CTH1 |
Gene Synonyms/Alias | YDR151C; YD8358.07C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 253 | KPCINWSKLGYCPYG | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Binds to specific AU-rich elements (ARE) in the 3'- untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Negatively regulates primarily iron-dependent mitochondrial processes including respiration and amino acid biosynthesis. |
Sequence Annotation | ZN_FING 204 232 C3H1-type 1.
ZN_FING 242 270 C3H1-type 2. |
Keyword | Complete proteome; Metal-binding; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 325 AA |
Protein Sequence | MMPNVAPNSY YLNIPNANST STTTSSIFSD LNKEYESKIK EIEEYYIKTL LNENTDNDDS 60
SSSEGHNINE TDILSEYSPR PSPWLPSKPN CYHPLGDFKD LIISDSRPTN TLPINNPFAG 120
NNNISTLATT EKKRKKRSLE VEINPTYTTS AFSLPLTAEN LQKLSQVDSQ STGLPYTLPI 180
QKTTKLEPCR RAPLQLPQLV NKTLYKTELC ESFTIKGYCK YGNKCQFAHG LNELKFKKKS 240
NNYRTKPCIN WSKLGYCPYG KRCCFKHGDD KDVEIYQNAN DGRSKDTALT PLPTSLAPSN 300
NDNITNLSKP RNLHTSVKAL QRMTW 325 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |