CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037127
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 SH2 domain-containing protein 3C 
Protein Synonyms/Alias
  
Gene Name
 SH2D3C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
272GLGQGSSKPASPVSPubiquitination[1]
509LEVGLLRKVKELLAEubiquitination[1]
511VGLLRKVKELLAEVDubiquitination[1]
541ARILGVTKEMQTLMGubiquitination[1]
652EGAILYEKKLKPFLKubiquitination[1]
653GAILYEKKLKPFLKSubiquitination[1]
782VLTALSHKLEPAVRSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 792 AA 
Protein Sequence
MAPALPSPHK AVARPELLLD TAAHSGKLRA PDGGEGAECA GHNGGPSWGV GQGQSQEPSR 60
QGIPQAPWLV SWQRRGFPPS SFCPGPLRTE KLRAGRCPLL LCGGAAGEPE AGSDYVKFSK 120
EKYILDSSPE KLHKELEEEL KLSSTDLRSH AWYHGRIPRE VSETLVQRNG DFLIRDSLTS 180
LGDYVLTCRW RNQALHFKIN KVVVKAGESY THIQYLFEQE SFDHVPALVR YHVGSRKAVS 240
EQSGAIIYCP VNRTFPLRYL EASYGLGQGS SKPASPVSPS GPKGSHMKRR SVTMTDGLTA 300
DKVTRSDGCP TSTSLPRPRD SIRSCALSMD QIPDLHSPMS PISESPSSPA YSTVTRVHAA 360
PAAPSATALP ASPVARRSSE PQLCPGSAPK THGESDKGPH TSPSHTLGKA SPSPSLSSYS 420
DPDSGHYCQL QPPVRGSREW AATETSSQQA RSYGERLKEL SENGAPEGDW GKTFTVPIVE 480
VTSSFNPATF QSLLIPRDNR PLEVGLLRKV KELLAEVDAR TLARHVTKVD CLVARILGVT 540
KEMQTLMGVR WGMELLTLPH GRQLRLDLLE RFHTMSIMLA VDILGCTGSA EERAALLHKT 600
IQLAAELRGT MGNMFSFAAV MGALDMAQIS RLEQTWVTLR QRHTEGAILY EKKLKPFLKS 660
LNEGKEGPPL SNTTFPHVLP LITLLECDSA PPEGPEPWGS TEHGVEVVLA HLEAARTVAH 720
HGGLYHTNAE VKLQGFQARP ELLEVFSTEF QMRLLWGSQG ASSSQARRYE KFDKVLTALS 780
HKLEPAVRSS EL 792 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR023578; Ras_GEF_dom.
 IPR001895; RasGRF_CDC25.
 IPR000980; SH2. 
Pfam
 PF00617; RasGEF
 PF00017; SH2 
SMART
 SM00147; RasGEF
 SM00252; SH2 
PROSITE
 PS50009; RASGEF_CAT
 PS50001; SH2 
PRINTS