UniProt Accession

 PWP1_HUMAN; Q13610; A8K3R6 

Genbank Protein ID

 L07758; AK290681; CH471054 

Genbank Nucleotide ID

 AAA65201.1; BAF83370.1; EAW97802.1 

Protein Name

 Periodic tryptophan protein 1 homolog 

Protein Synonyms/Alias

 Keratinocyte protein IEF SSP 9502 

Gene Name

 PWP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	KRLIAEAKEKLQEEG	ubiquitination	[1, 2, 3]
42	LIAEAKEKLQEEGGG	ubiquitination	[2]
408	LVTASADKYVKIWDI	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May play an important role in cell growth and/or transcription. 

Sequence Annotation

 REPEAT 186 230 WD 1.
 REPEAT 254 294 WD 2.
 REPEAT 297 337 WD 3.
 REPEAT 383 423 WD 4.
 REPEAT 428 468 WD 5.
 MOD_RES 50 50 Phosphoserine.
 MOD_RES 55 55 Phosphothreonine.
 MOD_RES 57 57 Phosphoserine.
 MOD_RES 59 59 Phosphoserine.
 MOD_RES 86 86 Phosphothreonine.
 MOD_RES 494 494 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 501 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; TAS:ProtInc. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.