CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013921
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leukocyte elastase inhibitor C 
Protein Synonyms/Alias
 Serine protease inhibitor EIC; Serpin B1c 
Gene Name
 Serpinb1c 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
87RGASHTLKLANRLYGacetylation[1]
298QDLFSSSKADLSGMSubiquitination[2]
314SRDLFISKIVHKSYVacetylation[1]
314SRDLFISKIVHKSYVubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Regulates the activity of the neutrophil proteases (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Protease inhibitor; Reference proteome; Serine protease inhibitor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 375 AA 
Protein Sequence
MGQLSSANNL FALELFHTLN ESNPTGNTIF SPVSISSALA MVYLGARGST AAQLSKTLHF 60
DSAEDIHSQF QSLTAEVSKR GASHTLKLAN RLYGEKTYNF LPEYLASIQK TYSADLALVD 120
FQHASEDARK EINQWVKGQT EEKIQELFAV GVVDSMTKLV LVNATYFKGM WQKKFMARDT 180
TDAPFRLSKK VTKTVKMMYL KNNLPFGYIP DLKCKVLEMP YQGGELSMVI LLPEDIEDET 240
TGLEEIEKQL TLEKLQECEN LQNIDVCVKL PKFKMEESYI LNSNLGQLGV QDLFSSSKAD 300
LSGMSGSRDL FISKIVHKSY VEVNEEGTET DAAMPGTVVG CCLMPMEFTV DHPFLFFIRH 360
NPTAHVLFLG RVCSP 375 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IBA:RefGenome.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome. 
Interpro
 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR015557; Protease_inhib_serpin_B1.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 
Pfam
 PF00079; Serpin 
SMART
 SM00093; SERPIN 
PROSITE
 PS00284; SERPIN 
PRINTS