CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037413
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transducin beta-like protein 2 
Protein Synonyms/Alias
  
Gene Name
 TBL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
227WEVCFGKKGEFQEVVubiquitination[1, 2]
263RRMASVSKDGTWKLWubiquitination[1]
278DTDVEYKKKQDPYLLubiquitination[1]
279TDVEYKKKQDPYLLKubiquitination[1]
286KQDPYLLKTGRFEEAubiquitination[1, 3]
328YNTRRGEKEECFERVacetylation[2]
381EEMQGHLKRASNESTubiquitination[1]
404TQAQETLKSLGALKKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 411 AA 
Protein Sequence
MGLSFSSGQK ANGFPPDKSS GSKKQKQYQR IRKEKPQQHN FTHRLLAAAL KSHSGNISCM 60
DFSSNGKYLA TCADDRTIRI WSTKDFLQRE HRSMRANVEL DHATLVRFSP DCRAFIVWLA 120
NGDTLRVFKM TKREDGGYTF TATPEDFPKK HKAPVIDIGI ANTGKFIMTA SSDTTVLIWS 180
LKGQVLSTIN TNQMNNTHAA VSPCGRFVAS CGFTPDVKVW EVCFGKKGEF QEVVRAFELK 240
GHSAAVHSFA FSNDSRRMAS VSKDGTWKLW DTDVEYKKKQ DPYLLKTGRF EEAAGAAPCR 300
LALSPNAQVL ALASGSSIHL YNTRRGEKEE CFERVHGECI ANLSFDITGR FLASCGDRAV 360
RLFHNTPGHR AMVEEMQGHL KRASNESTRQ RLQQQLTQAQ ETLKSLGALK K 411 
Gene Ontology
  
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.