UniProt Accession

 J3KTB7_HUMAN; J3KTB7 

Genbank Protein ID

 AC080112 

Genbank Nucleotide ID

  

Protein Name

 DNA topoisomerase 2-alpha 

Protein Synonyms/Alias

  

Gene Name

 TOP2A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
89	DNKQRDPKMSCIRVT	ubiquitination	[1]
111	ISIWNNGKGIPVVEH	ubiquitination	[1, 2, 3]
144	SNYDDDEKKVT****	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0000793; C:condensed chromosome; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003918; F:DNA topoisomerase type II (ATP-hydrolyzing) activity; IEA:Compara.
 GO:0030261; P:chromosome condensation; IEA:Compara.
 GO:0007059; P:chromosome segregation; IEA:Compara.
 GO:0006265; P:DNA topological change; IEA:Compara.
 GO:0040016; P:embryonic cleavage; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR003594; HATPase_ATP-bd.
 IPR001241; Topo_IIA. 

Pfam

 PF02518; HATPase_c 

SMART

  

PROSITE

  

PRINTS

 PR00418; TPI2FAMILY.