UniProt Accession

 ASF1A_HUMAN; Q9Y294; Q6IA08; Q9P014 

Genbank Protein ID

 AB028628; AF279306; AF151856; AF161495; AL050261; AK025738; CR457347; AC022098; BC010878 

Genbank Nucleotide ID

 BAA96542.1; AAK82972.1; AAD34093.1; AAF29110.1; CAB43363.1; BAB15228.1; CAG33628.1; AAH10878.1 

Protein Name

 Histone chaperone ASF1A 

Protein Synonyms/Alias

 Anti-silencing function protein 1 homolog A; hAsf1; hAsf1a; CCG1-interacting factor A; CIA; hCIA 

Gene Name

 ASF1A 

Gene Synonyms/Alias

 CGI-98; HSPC146 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
129	LRENPPVKPDFSKLQ	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. 

Sequence Annotation

 REGION 1 156 Interaction with histone H3, CHAF1B, and
 REGION 155 204 Required for interaction with HIRA.
 MOTIF 31 37 Required for interaction with HIRA.
 MOD_RES 192 192 Phosphoserine; by TLK2.  

Keyword

 3D-structure; Chaperone; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003682; F:chromatin binding; NAS:UniProtKB.
 GO:0042393; F:histone binding; IDA:MGI.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IDA:MGI.
 GO:0042692; P:muscle cell differentiation; IEA:Compara.
 GO:0031936; P:negative regulation of chromatin silencing; NAS:UniProtKB.
 GO:0006334; P:nucleosome assembly; IDA:MGI.
 GO:0001649; P:osteoblast differentiation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR006818; Histone_chaperone_ASF1-like. 

Pfam

 PF04729; ASF1_hist_chap 

SMART

  

PROSITE

  

PRINTS