CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023177
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pleckstrin homology domain-containing family G member 1 
Protein Synonyms/Alias
  
Gene Name
 PLEKHG1 
Gene Synonyms/Alias
 KIAA1209 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1247LTLQDSQKVVVVNRNacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 DOMAIN 113 293 DH.
 DOMAIN 317 416 PH.
 MOD_RES 1192 1192 Phosphoserine.  
Keyword
 Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1385 AA 
Protein Sequence
MELSDSDRPV SFGSTSSSAS SRDSHGSFGS RMTLVSNSHM GLFNQDKEVG AIKLELIPAR 60
PFSSSELQRD NPATGQQNAD EGSERPPRAQ WRVDSNGAPK TIADSATSPK LLYVDRVVQE 120
ILETERTYVQ DLKSIVEDYL DCIRDQTKLP LGTEERSALF GNIQDIYHFN SELLQDLENC 180
ENDPVAIAEC FVSKSEEFHI YTQYCTNYPR SVAVLTECMR NKILAKFFRE RQETLKHSLP 240
LGSYLLKPVQ RILKYHLLLH EIENHLDKDT EGYDVVLDAI DTMQRVAWHI NDMKRKHEHA 300
VRLQEIQSLL TNWKGPDLTS YGELVLEGTF RIQRAKNERT LFLFDKLLLI TKKRDDTFTY 360
KAHILCGNLM LVEVIPKEPL SFSVFHYKNP KLQHTVQAKS QQDKRLWVLH LKRLILENHA 420
AKIPAKAKQA ILEMDAIHHP GFCYSPEGGT KALFGSKEGS APYRLRRKSE PSSRSHKVLK 480
TSETAQDIQK VSREEGSPQL SSARPSPAQR NSQPSSSTMI SVLRAGGALR NIWTDHQIRQ 540
ALFPSRRSPQ ENEDDEDDYQ MFVPSFSSSD LNSTRLCEDS TSSRPCSWHM GQMESTETSS 600
SGHRIVRRAS SAGESNTCPP EIGTSDRTRE LQNSPKTEGQ EEMTPFGSSI ELTIDDIDHV 660
YDNISYEDLK LMVAKREEAE STPSKSARDS VRPKSTPELA FTKRQAGHSK GSLYAQTDGT 720
LSGGEASSQS THELQAVEEN IYDTIGLPDP PSLGFKCSSL KRAKRSTFLG LEADFVCCDS 780
LRPFVSQDSL QLSEDEAPYH QATPDHGYLS LLYDSPSGNL SMPHKPVSDK LSEEVDEIWN 840
DLENYIKKNE DKARDRLLAA FPVSKDDVPD RLHAESTPEL SRDVGRSVST LSLPESQALL 900
TPVKSRAGRA SRANCPFEED LISKEGSFMS LNRLSLASEM PLMDNPYDLA NSGLSQTDPE 960
NPDLGMEATD KTKSRVFMMA RQYSQKIKKA NQLLKVKSLE LEQPPASQHQ KSMHKDLAAI 1020
LEEKKQGGPA IGARIAEYSQ LYDQIVFRES PLKIQKDGWA SPQESSLLRS VSPSQVHHGS 1080
GDWLLHSTYS NGELADFCLP PEQDLRSRYP TFEINTKSTP RQLSAACSVP SLQTSDPLPG 1140
SVQRCSVVVS QPNKENWCQD HLYNSLGRKG ISAKSQPYHR SQSSSSVLIN KSMDSINYPS 1200
DVGKQQLLSL HRSSRCESHQ DLLPDIADSH QQGTEKLSDL TLQDSQKVVV VNRNLPLNAQ 1260
IATQNYFSNF KETDGDEDDY VEIKSEEDES ELELSHNRRR KSDSKFVDAD FSDNVCSGNT 1320
LHSLNSPRTP KKPVNSKLGL SPYLTPYNDS DKLNDYLWRG PSPNQQNIVQ SLREKFQCLS 1380
SSSFA 1385 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00621; RhoGEF 
SMART
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN 
PRINTS