CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023980
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transforming acidic coiled-coil-containing protein 3 
Protein Synonyms/Alias
 ERIC-1 
Gene Name
 TACC3 
Gene Synonyms/Alias
 ERIC1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
550QFGTSSFKESALRKQubiquitination[1]
562RKQSLYLKFDPLLRDubiquitination[1, 2, 3, 4]
649KDLDAVVKATQEENRubiquitination[1, 3, 5]
674GKNLELGKIMDRFEEubiquitination[1, 2, 4]
819KTVEQKTKENEELTRubiquitination[5]
834ICDDLISKMEKI***ubiquitination[5, 6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May be involved in the control of cell growth and differentiation. May contribute to cancer. 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 25 25 Phosphoserine.
 MOD_RES 39 39 Phosphoserine.
 MOD_RES 71 71 Phosphoserine.
 MOD_RES 175 175 Phosphoserine.
 MOD_RES 317 317 Phosphoserine.
 MOD_RES 402 402 Phosphoserine.
 MOD_RES 434 434 Phosphoserine.
 MOD_RES 558 558 Phosphoserine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 838 AA 
Protein Sequence
MSLQVLNDKN VSNEKNTENC DFLFSPPEVT GRSSVLRVSQ KENVPPKNLA KAMKVTFQTP 60
LRDPQTHRIL SPSMASKLEA PFTQDDTLGL ENSHPVWTQK ENQQLIKEVD AKTTHGILQK 120
PVEADTDLLG DASPAFGSGS SSESGPGALA DLDCSSSSQS PGSSENQMVS PGKVSGSPEQ 180
AVEENLSSYS LDRRVTPASE TLEDPCRTES QHKAETPHGA EEECKAETPH GAEEECRHGG 240
VCAPAAVATS PPGAIPKEAC GGAPLQGLPG EALGCPAGVG TPVPADGTQT LTCAHTSAPE 300
STAPTNHLVA GRAMTLSPQE EVAAGQMASS SRSGPVKLEF DVSDGATSKR APPPRRLGER 360
SGLKPPLRKA AVRQQKAPQE VEEDDGRSGA GEDPPMPASR GSYHLDWDKM DDPNFIPFGG 420
DTKSGCSEAQ PPESPETRLG QPAAEQLHAG PATEEPGPCL SQQLHSASAE DTPVVQLAAE 480
TPTAESKERA LNSASTSLPT SCPGSEPVPT HQQGQPALEL KEESFRDPAE VLGTGAEVDY 540
LEQFGTSSFK ESALRKQSLY LKFDPLLRDS PGRPVPVATE TSSMHGANET PSGRPREAKL 600
VEFDFLGALD IPVPGPPPGV PAPGGPPLST GPIVDLLQYS QKDLDAVVKA TQEENRELRS 660
RCEELHGKNL ELGKIMDRFE EVVYQAMEEV QKQKELSKAE IQKVLKEKDQ LTTDLNSMEK 720
SFSDLFKRFE KQKEVIEGYR KNEESLKKCV EDYLARITQE GQRYQALKAH AEEKLQLANE 780
EIAQVRSKAQ AEALALQASL RKEQMRIQSL EKTVEQKTKE NEELTRICDD LISKMEKI 838 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0030953; P:astral microtubule organization; IEA:Compara.
 GO:0021987; P:cerebral cortex development; IEA:Compara.
 GO:0042994; P:cytoplasmic sequestering of transcription factor; IEA:Compara.
 GO:0030097; P:hemopoiesis; IEA:Compara.
 GO:0022027; P:interkinetic nuclear migration; IEA:Compara.
 GO:0022008; P:neurogenesis; IEA:Compara.
 GO:0051726; P:regulation of cell cycle; IEA:Compara.
 GO:0032886; P:regulation of microtubule-based process; IEA:Compara.
 GO:0006950; P:response to stress; IEA:Compara. 
Interpro
 IPR007707; TACC. 
Pfam
 PF05010; TACC 
SMART
  
PROSITE
  
PRINTS