UniProt Accession

 STX2_HUMAN; P32856; Q86VW8 

Genbank Protein ID

 D14582; AC073912; BC047496 

Genbank Nucleotide ID

 BAA03436.1; AAH47496.1 

Protein Name

 Syntaxin-2 

Protein Synonyms/Alias

 Epimorphin 

Gene Name

 STX2 

Gene Synonyms/Alias

 EPIM; STX2A; STX2B; STX2C 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	SAPNPEGKIKEELED	ubiquitination	[1]
125	QHSVLSRKFVEAMAE	methylation	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. 

Sequence Annotation

 DOMAIN 191 253 t-SNARE coiled-coil homology.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IDA:HGNC.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005911; C:cell-cell junction; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; TAS:ProtInc.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0048306; F:calcium-dependent protein binding; ISS:HGNC.
 GO:0007340; P:acrosome reaction; ISS:HGNC.
 GO:0030154; P:cell differentiation; IEA:Compara.
 GO:0007398; P:ectoderm development; TAS:ProtInc.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0009887; P:organ morphogenesis; TAS:ProtInc.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE
 PF00804; Syntaxin 

SMART

 SM00503; SynN
 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS