| Tag | Content |
|---|
| CPLM ID | CPLM-022159 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Muscleblind-like protein 3 |
Protein Synonyms/Alias | Cys3His CCG1-required protein; Muscleblind-like X-linked protein; Protein HCHCR |
Gene Name | MBNL3 |
Gene Synonyms/Alias | CHCR; MBLX39; MBXL |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 59 | VACFDSLKGRCTREN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. |
Sequence Annotation | ZN_FING 14 42 C3H1-type 1.
ZN_FING 48 74 C3H1-type 2.
ZN_FING 174 202 C3H1-type 3.
ZN_FING 210 236 C3H1-type 4. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 354 AA |
Protein Sequence | MTAVNVALIR DTKWLTLEVC REFQRGTCSR ADADCKFAHP PRVCHVENGR VVACFDSLKG 60
RCTRENCKYL HPPPHLKTQL EINGRNNLIQ QKTAAAMFAQ QMQLMLQNAQ MSSLGSFPMT 120
PSIPANPPMA FNPYIPHPGM GLVPAELVPN TPVLIPGNPP LAMPGAVGPK LMRSDKLEVC 180
REFQRGNCTR GENDCRYAHP TDASMIEASD NTVTICMDYI KGRCSREKCK YFHPPAHLQA 240
RLKAAHHQMN HSAASAMALQ PGTLQLIPKR SALEKPNGAT PVFNPTVFHC QQALTNLQLP 300
QPAFIPAGPI LCMAPASNIV PMMHGATPTT VSAATTPATS VPFAAPTTGN QLKF 354 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IDA:HPA. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0045662; P:negative regulation of myoblast differentiation; IEA:Compara. GO:0043484; P:regulation of RNA splicing; IDA:UniProtKB. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |