CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011896
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HMG domain-containing protein 3 
Protein Synonyms/Alias
 HMG box-containing protein 3; Protein SMF 
Gene Name
 HMGXB3 
Gene Synonyms/Alias
 KIAA0194; SMF 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
345LEKAKLEKEGLDPNSubiquitination[1]
353EGLDPNSKLSALTAVubiquitination[1, 2]
629TTEQNSSKENASKLTubiquitination[1]
905DRTEKTTKAIEVSSPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 DNA_BIND 288 356 HMG box.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1538 AA 
Protein Sequence
MQRTQPRPCY LNAPQQCPGA ERPGRPTAGS HSFLLRPGPL AGSSPFALLD PLQAFEQFVW 60
VRSQARAGLL RLRQGSHAVT RCRPLPVRRE GRRDGSPWRS VVCRYCRCSR QTGASVTTVS 120
LPSSSSSPGL DPRGPRQASV RSLRSEPVLL FLPFRTPYRD SEEGKREGLS RLRAVCRRAG 180
PRGRGSFSPR DARASPRLHF LVAAVTTGAA SRRQRGARVR QPSPSSSRRA KRLRECERRS 240
LHAPPAMDAS YDGTEVTVVM EEIEEAYCYT SPGPPKKKKK YKIHGEKTKK PRSAYLLYYY 300
DIYLKVQQEL PHLPQSEINK KISESWRLLS VAERSYYLEK AKLEKEGLDP NSKLSALTAV 360
VPDIPGFRKI LPRSDYIIIP KSSLQEDRSC PQLELCVAQN QMSPKGPPLV SNTAPETVPS 420
HAGMAEQCLA VEALAEEVGA LTQSGAVQEI ATSEILSQDV LLEDASLEVG ESHQPYQTSL 480
VIEETLVNGS PDLPTGSLAV PHPQVGESVS VVTVMRDSSE SSSSAPATQF IMLPLPAYSV 540
VENPTSIKLT TTYTRRGHGT CTSPGCSFTY VTRHKPPKCP TCGNFLGGKW IPKEKPAKVK 600
VELASGVSSK GSVVKRNQQP VTTEQNSSKE NASKLTLENS EAVSQLLNVA PPREVGEESE 660
WEEVIISDAH VLVKEAPGNC GTAVTKTPVV KSGVQPEVTL GTTDNDSPGA DVPTPSEGTS 720
TSSPLPAPKK PTGADLLTPG SRAPELKGRA RGKPSLLAAA RPMRAILPAP VNVGRGSSMG 780
LPRARQAFSL SDKTPSVRTC GLKPSTLKQL GQPIQQPSGP GEVKLPSGPS NRTSQVKVVE 840
VKPDMFPPYK YSCTVTLDLG LATSRGRGKC KNPSCSYVYT NRHKPRICPS CGVNLAKDRT 900
EKTTKAIEVS SPLPDVLNAT EPLSTAQREI QRQSTLQLLR KVLQIPENES ELAEVFALIH 960
ELNSSRLILS NVSEETVTIE QTSWSNYYES PSTQCLLCSS PLFKGGQNSL AGPQECWLLT 1020
ASRLQTVTAQ VKMCLNPHCL ALHSFIDIYT GLFNVGNKLL VSLDLLFAIR NQIKLGEDPR 1080
VSINVVLKSV QEQTEKTLTS EELSQLQELL CNGYWAFECL TVRDYNDMIC GICGVAPKVE 1140
MAQRSEENVL ALKSVEFTWP EFLGSNEVNV EDFWATMETE VIEQVAFPAS IPITKFDASV 1200
IAPFFPPLMR GAVVVNTEKD KNLDVQPVPG SGSALVRLLQ EGTCKLDEIG SYSEEKLQHL 1260
LRQCGIPFGA EDSKDQLCFS LLALYESVQN GARAIRPPRH FTGGKIYKVC PHQVVCGSKY 1320
LVRGESARDH VDLLASSRHW PPVYVVDMAT SVALCADLCY PELTNQMWGR NQGCFSSPTE 1380
PPVSVSCPEL LDQHYTVDMT ETEHSIQHPV TKTATRRIVH AGLQPNPGDP SAGHHSLALC 1440
PELAPYATIL ASIVDSKPNG VRQRPIAFDN ATHYYLYNRL MDFLTSREIV NRQIHDIVQS 1500
CQPGEVVIRD TLYRLGVAQI KTETEEEGEE EEVAAVAE 1538 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; NAS:UniProtKB. 
Interpro
 IPR009071; HMG_box_dom. 
Pfam
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS