CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018399
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG 
Protein Synonyms/Alias
 Glucose-inhibited division protein A 
Gene Name
 mnmG 
Gene Synonyms/Alias
 gidA; STM3874 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
149MGLKFRAKAVVLTVGacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity). 
Sequence Annotation
 NP_BIND 13 18 FAD (By similarity).
 NP_BIND 273 287 NAD (Potential).
 BINDING 125 125 FAD; via amide nitrogen and carbonyl
 BINDING 180 180 FAD (By similarity).
 BINDING 370 370 FAD (By similarity).  
Keyword
 Complete proteome; Cytoplasm; FAD; Flavoprotein; NAD; Reference proteome; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 629 AA 
Protein Sequence
MFYQDPFDVI IIGGGHAGTE AAMAAARMGQ QTLLLTHNID TLGQMSCNPA IGGIGKGHLV 60
KEVDALGGLM AKAIDQAGIQ FRILNASKGP AVRATRAQAD RVLYRQAVRT ALENQPNLMI 120
FQQAVEDLIV ENDRVVGAVT QMGLKFRAKA VVLTVGTFLD GKIHIGLDNY SGGRAGDPPS 180
IPLSRRLREL PLRVSRLKTG TPPRIDARTI DFSVLAQQHG DNPMPVFSFM GNASQHPQQV 240
PCYITHTNEK THDVIRNNLD RSPMYAGVIE GIGPRYCPSI EDKVMRFADR NQHQIFLEPE 300
GLTSNEIYPN GISTSLPFDV QMQIVRSMQG MENAKIVRPG YAIEYDFFDP RDLKPTLESK 360
FIHGLFFAGQ INGTTGYEEA AAQGLLAGLN AARLSADKEG WAPARSQAYL GVLVDDLCTL 420
GTKEPYRMFT SRAEYRLMLR EDNADLRLTE MGRELGLVDD ERWARFNEKL ENIERERQRL 480
KSTWVTPSAE SADEVNAHLT TPLSREASGE DLLRRPEMTY AQLTSLAAFA PALEDEQAAE 540
QVEIQVKYEG YIARQQDEIE KQLRNENTLL PATLDYRQVS GLSNEVIAKL NDHKPASIGQ 600
ASRISGVTPA AISILLVWLK KQGMLRRSA 629 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:HAMAP.
 GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro. 
Interpro
 IPR004416; GidA.
 IPR026904; GidA-assoc_3.
 IPR002218; GIDA-rel.
 IPR020595; GIDA-rel_CS. 
Pfam
 PF01134; GIDA
 PF13932; GIDA_assoc_3 
SMART
  
PROSITE
 PS01280; GIDA_1
 PS01281; GIDA_2 
PRINTS