CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019766
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ataxin-2 
Protein Synonyms/Alias
 Spinocerebellar ataxia type 2 protein; Trinucleotide repeat-containing gene 13 protein 
Gene Name
 ATXN2 
Gene Synonyms/Alias
 ATX2; SCA2; TNRC13 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
300VFKTYSPKCDLVLDAubiquitination[1]
349DMDSSYAKRDAFTDSubiquitination[1, 2]
436DNSEEFLKREARANQubiquitination[1, 2]
455IESSAQYKARVALENubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. 
Sequence Annotation
 MOD_RES 393 393 Phosphoserine.
 MOD_RES 466 466 Phosphoserine.
 MOD_RES 554 554 Phosphoserine.
 MOD_RES 644 644 Phosphoserine (By similarity).
 MOD_RES 684 684 Phosphoserine.
 MOD_RES 741 741 Phosphothreonine.
 MOD_RES 772 772 Phosphoserine (By similarity).
 MOD_RES 784 784 Phosphoserine.
 MOD_RES 857 857 Phosphoserine.
 MOD_RES 861 861 Phosphoserine.
 MOD_RES 865 865 Phosphoserine.
 MOD_RES 888 888 Phosphoserine.
 MOD_RES 889 889 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Amyotrophic lateral sclerosis; Complete proteome; Cytoplasm; Neurodegeneration; Parkinsonism; Phosphoprotein; Polymorphism; Reference proteome; Spinocerebellar ataxia; Triplet repeat expansion. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1313 AA 
Protein Sequence
MRSAAAAPRS PAVATESRRF AAARWPGWRS LQRPARRSGR GGGGAAPGPY PSAAPPPPGP 60
GPPPSRQSSP PSASDCFGSN GNGGGAFRPG SRRLLGLGGP PRPFVVLLLP LASPGAPPAA 120
PTRASPLGAR ASPPRSGVSL ARPAPGCPRP ACEPVYGPLT MSLKPQQQQQ QQQQQQQQQQ 180
QQQQQQQQPP PAAANVRKPG GSGLLASPAA APSPSSSSVS SSSATAPSSV VAATSGGGRP 240
GLGRGRNSNK GLPQSTISFD GIYANMRMVH ILTSVVGSKC EVQVKNGGIY EGVFKTYSPK 300
CDLVLDAAHE KSTESSSGPK REEIMESILF KCSDFVVVQF KDMDSSYAKR DAFTDSAISA 360
KVNGEHKEKD LEPWDAGELT ANEELEALEN DVSNGWDPND MFRYNEENYG VVSTYDSSLS 420
SYTVPLERDN SEEFLKREAR ANQLAEEIES SAQYKARVAL ENDDRSEEEK YTAVQRNSSE 480
REGHSINTRE NKYIPPGQRN REVISWGSGR QNSPRMGQPG SGSMPSRSTS HTSDFNPNSG 540
SDQRVVNGGV PWPSPCPSPS SRPPSRYQSG PNSLPPRAAT PTRPPSRPPS RPSRPPSHPS 600
AHGSPAPVST MPKRMSSEGP PRMSPKAQRH PRNHRVSAGR GSISSGLEFV SHNPPSEAAT 660
PPVARTSPSG GTWSSVVSGV PRLSPKTHRP RSPRQNSIGN TPSGPVLASP QAGIIPTEAV 720
AMPIPAASPT PASPASNRAV TPSSEAKDSR LQDQRQNSPA GNKENIKPNE TSPSFSKAEN 780
KGISPVVSEH RKQIDDLKKF KNDFRLQPSS TSESMDQLLN KNREGEKSRD LIKDKIEPSA 840
KDSFIENSSS NCTSGSSKPN SPSISPSILS NTEHKRGPEV TSQGVQTSSP ACKQEKDDKE 900
EKKDAAEQVR KSTLNPNAKE FNPRSFSQPK PSTTPTSPRP QAQPSPSMVG HQQPTPVYTQ 960
PVCFAPNMMY PVPVSPGVQP LYPIPMTPMP VNQAKTYRAV PNMPQQRQDQ HHQSAMMHPA 1020
SAAGPPIAAT PPAYSTQYVA YSPQQFPNQP LVQHVPHYQS QHPHVYSPVI QGNARMMAPP 1080
THAQPGLVSS SATQYGAHEQ THAMYACPKL PYNKETSPSF YFAISTGSLA QQYAHPNATL 1140
HPHTPHPQPS ATPTGQQQSQ HGGSHPAPSP VQHHQHQAAQ ALHLASPQQQ SAIYHAGLAP 1200
TPPSMTPASN TQSPQNSFPA AQQTVFTIHP SHVQPAYTNP PHMAHVPQAH VQSGMVPSHP 1260
TAHAPMMLMT TQPPGGPQAA LAQSALQPIP VSTTAHFPYM THPSVQAHHQ QQL 1313 
Gene Ontology
 GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005844; C:polysome; IDA:UniProtKB.
 GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
 GO:0003723; F:RNA binding; NAS:UniProtKB.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Compara.
 GO:0033962; P:cytoplasmic mRNA processing body assembly; IMP:UniProtKB.
 GO:0048872; P:homeostasis of number of cells; IEA:Compara.
 GO:0040015; P:negative regulation of multicellular organism growth; IEA:Compara.
 GO:0002091; P:negative regulation of receptor internalization; IMP:UniProtKB.
 GO:0050905; P:neuromuscular process; IEA:Compara.
 GO:0048812; P:neuron projection morphogenesis; IEA:Compara.
 GO:0006417; P:regulation of translation; NAS:UniProtKB.
 GO:0016070; P:RNA metabolic process; NAS:UniProtKB.
 GO:0050658; P:RNA transport; NAS:UniProtKB.
 GO:0034063; P:stress granule assembly; IMP:UniProtKB. 
Interpro
 IPR009818; Ataxin-2_C.
 IPR010920; LSM_dom.
 IPR009604; LsmAD_domain.
 IPR025852; SM_dom_ATX. 
Pfam
 PF06741; LsmAD
 PF07145; PAM2
 PF14438; SM-ATX 
SMART
  
PROSITE
  
PRINTS