CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013476
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 
Protein Synonyms/Alias
 Complex I-42kD; CI-42kD; NADH-ubiquinone oxidoreductase 42 kDa subunit 
Gene Name
 Ndufa10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
191VDHYNEIKRLTLPEYacetylation[1]
228KGDPHEMKVTSAYLQacetylation[1]
242QDIEDAYKKTFLPKMacetylation[1]
280IEYLNYNKGPWLKQDacetylation[1]
285YNKGPWLKQDDRTFHacetylation[1]
301LRMLVQDKREVLNYTacetylation[1]
350YNADVGDKWIWLK**acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 
Sequence Annotation
 MOD_RES 122 122 N6-acetyllysine (By similarity).
 MOD_RES 181 181 N6-acetyllysine (By similarity).
 MOD_RES 242 242 N6-acetyllysine (By similarity).
 MOD_RES 350 350 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Electron transport; FAD; Flavoprotein; Mitochondrion; Reference proteome; Respiratory chain; Transit peptide; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 355 AA 
Protein Sequence
MALRLLRLVP ASASARGLAA GAQRVGRIHT SVHCKLRYGL LASILGDKTT KKLHEYSRVI 60
TVDGNICSGK NKLARDIAEQ LGMKHYPEAG IQYSSSTTGD GRPLDIEFSG SCSLEKFYDN 120
PKSNDGNSYR LQSWLYASRL LQYSDALEHL LSTGQGVVLE RSIYSDFVFL EAMYNQGFIR 180
KQCVDHYNEI KRLTLPEYLP PHAVIYIDVP VSEIQSRIQK KGDPHEMKVT SAYLQDIEDA 240
YKKTFLPKMS EICEVLVYSS WEAEDSTKVV EDIEYLNYNK GPWLKQDDRT FHNLRMLVQD 300
KREVLNYTTV PVYLPEITIG AHQGSRIYDS FRELPGRKYA PGYNADVGDK WIWLK 355 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
 GO:0042493; P:response to drug; IEP:RGD. 
Interpro
 IPR002624; Deoxynucleoside_kinase.
 IPR015828; NADH_UbQ_OxRdtase_42KD_su.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01712; dNK 
SMART
  
PROSITE
  
PRINTS