CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019726
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Perilipin-2 
Protein Synonyms/Alias
 Adipophilin; Adipose differentiation-related protein; ADRP 
Gene Name
 PLIN2 
Gene Synonyms/Alias
 ADFP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
140TITGVMDKTKGAVTGubiquitination[1, 2]
153TGSVEKTKSVVSGSIubiquitination[2]
273NVYSANQKIQDAQDKubiquitination[2]
375DSLLTSSKGQLQKMKubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May be involved in development and maintenance of adipose tissue (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Lipoprotein; Membrane; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 437 AA 
Protein Sequence
MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA ENGVKTITSV 60
AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP STQIVANAKG AVTGAKDAVT 120
TTVTGAKDSV ASTITGVMDK TKGAVTGSVE KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL 180
TKSELLVEQY LPLTEEELEK EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK 240
EAKQKSQQTI SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES 300
HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA GDIYSVFRNA 360
ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW LVGPFYPQLT ESQNAQDQGA 420
EMDKSSQETQ RSEHKTH 437 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
 GO:0005576; C:extracellular region; TAS:ProtInc.
 GO:0005811; C:lipid particle; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.
 GO:0019915; P:lipid storage; IEA:Compara.
 GO:0015909; P:long-chain fatty acid transport; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 
Interpro
 IPR004279; Perilipin. 
Pfam
 PF03036; Perilipin 
SMART
  
PROSITE
  
PRINTS