| Tag | Content |
|---|
| CPLM ID | CPLM-010660 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Telomerase protein component 1 |
Protein Synonyms/Alias | Telomerase-associated protein 1; Telomerase protein 1; p240; p80 telomerase homolog |
Gene Name | Tep1 |
Gene Synonyms/Alias | Tp1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1348 | EELALYGKRLEESPF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). |
Sequence Annotation | REPEAT 1 30 TEP1 N-terminal 1.
REPEAT 31 60 TEP1 N-terminal 2.
REPEAT 61 90 TEP1 N-terminal 3.
REPEAT 91 120 TEP1 N-terminal 4.
DOMAIN 227 685 TROVE.
DOMAIN 1171 1578 NACHT.
REPEAT 1420 1462 WD 1.
REPEAT 1681 1720 WD 2.
REPEAT 1723 1761 WD 3.
REPEAT 1764 1803 WD 4.
REPEAT 1805 1844 WD 5.
REPEAT 1847 1886 WD 6.
REPEAT 1889 1930 WD 7.
REPEAT 1932 1971 WD 8.
REPEAT 1974 2013 WD 9.
REPEAT 2015 2054 WD 10.
REPEAT 2067 2106 WD 11.
REPEAT 2113 2151 WD 12.
REPEAT 2154 2191 WD 13.
REPEAT 2193 2241 WD 14.
REPEAT 2244 2282 WD 15.
REPEAT 2285 2324 WD 16.
REPEAT 2326 2362 WD 17.
REPEAT 2375 2424 WD 18.
REPEAT 2467 2507 WD 19.
REPEAT 2555 2592 WD 20.
REPEAT 2594 2628 WD 21.
NP_BIND 1177 1184 ATP (Potential). |
Keyword | ATP-binding; Chromosome; Complete proteome; Nucleotide-binding; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Telomere; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2629 AA |
Protein Sequence | MEKLCGHVPG HSDILSLKNR CLTMLPDLQP LEKIHGHRSV HSDILSLENQ CLTMLSDLQP 60
TERIDGHISV HPDILSLENR CLTMLPDLQP LEKLCGHMSS HPDVLSLENQ CLATLPTVKS 120
TALTSPLLQG LHISHTAQAD LHSLKTSNCL LPELPTKKTP CFSEELDLPP GPRALKSMSA 180
TAQVQEVALG QWCVSKEKEF QEEESTEVPM PLYSLSLEEE EVEAPVLKLT SGDSGFHPET 240
TDQVLQEKKM ALLTLLCSAL ASNVNVKDAS DLTRASILEV CSALASLEPE FILKASLYAR 300
QQLNLRDIAN TVLAVAALLP ACRPHVRRYY SAIVHLPSDW IQVAEFYQSL AEGDEKKLVS 360
LPACLRAAMT DKFAEFDEYQ LAKYNPRKHR SKRRSRQPPR PQKTERPFSE RGKCFPKSLW 420
PLKNEQITFE AAYNAMPEKN RLPRFTLKKL VEYLHIHKPA QHVQALLGYR YPATLELFSR 480
SHLPGPWESS RAGQRMKLRR PETWERELSL RGNKASVWEE LIDNGKLPFM AMLRNLCNLL 540
RTGISARHHE LVLQRLQHEK SVVHSRQFPF RFLNAHDSID KLEAQLRSKA SPFPSNTTLM 600
KRIMIRNSKK NRRPASRKHL CTLTRRQLRA AMTIPVMYEQ LKREKLRLHK ARQWNCDVEL 660
LERYRQALET AVNLSVKHNL SPMPGRTLLV YLTDANADRL CPKSHSQGPP LNYVLLLIGM 720
MVARAEQVTV CLCGGGFVKT PVLTADEGIL KTAIKLQAQV QELEGNDEWP LDTFGKYLLS 780
LAVQRTPIDR VILFGQRMDT ELLKVAKQII WQHVNSKCLF VGVLLQKTQY ISPNLNPNDV 840
TLSGCTDGIL KFIAEHGASR LLEHVGQLDK LFKIPPPPGK TQAPSLRPLE ENIPGPLGPI 900
SQHGWRNIRL FISSTFRDMH GERDLLMRSV LPALQARVFP HRISLHAIDL RWGITEEETR 960
RNRQLEVCLG EVENSQLFVG ILGSRYGYIP PSYDLPDHPH FHWTHEYPSG RSVTEMEVMQ 1020
FLNRGQRSQP SAQALIYFRD PDFLSSVPDA WKPDFISESE EAAHRVSELK RYLHEQKEVT 1080
CRSYSCEWGG VAAGRPYTGG LEEFGQLVLQ DVWSMIQKQH LQPGAQLEQP TSISEDDLIQ 1140
TSFQQLKTPT SPARPRLLQD TVQQLLLPHG RLSLVTGQAG QGKTAFLASL VSALKVPDQP 1200
NEPPFVFFHF AAARPDQCLA LNLLRRLCTH LRQKLGELSA LPSTYRGLVW ELQQKLLLKF 1260
AQSLQPAQTL VLIIDGADKL VDRNGQLISD WIPKSLPRRV HLVLSVSSDS GLGETLQQSQ 1320
GAYVVALGSL VPSSRAQLVR EELALYGKRL EESPFNNQMR LLLAKQGSSL PLYLHLVTDY 1380
LRLFTLYEQV SERLRTLPAT LPLLLQHILS TLEQEHGHDV LPQALTALEV TRSGLTVDQL 1440
HAILSTWLIL PKETKSWEEV LAASHSGNPF PLCPFAYLVQ SLRSLLGEGP VERPGARLCL 1500
SDGPLRTTIK RRYGKRLGLE KTAHVLIAAH LWKTCDPDAS GTFRSCPPEA LKDLPYHLLQ 1560
SGNHGLLAEF LTNLHVVAAY LEVGLVPDLL EAHVLYASSK PEANQKLPAA DVAVFHTFLR 1620
QQASLLTQYP LLLLQQAASQ PEESPVCCQA PLLTQRWHDQ FTLKWINKPQ TLKGQQSLSL 1680
TMSSSPTAVA FSPNGQRAAV GTASGTIYLL NLKTWQEEKA VVSGCDGISS FAFLSDTALF 1740
LTTFDGHLEL WDLQHGCWVF QTKAHQYQIT GCCLSPDRRL LATVCLGGYL KLWDTVRGQL 1800
AFQYTHPKSL NCVAFHPEGQ VVATGSWAGS ITFFQADGLK VTKELGAPGP SVCSLAFNKP 1860
GKIVAVGRID GTVELWAWQE GARLAAFPAQ CGCVSAVLFL HAGDRFLTAG EDGKAQLWSG 1920
FLGRPRGCLG SLPLSPALSV ALNPDGDQVA VGYREDGINI YKISSGSQGP QHQELNVAVS 1980
ALVWLSPSVL VSGAEDGSLH GWMFKGDSLH SLWLLSRYQK PVLGLAASRE LMAAASEDFT 2040
VRLWPRQLLT QPHVHAVELP CCAELRGHEG PVCCCSFSPD GGILATAGRD RNLLCWDMKI 2100
AQAPLLIHTF SSCHRDWITG CAWTKDNILV SCSSDGSVGL WNPEAGQQLG QFSGHQSAVS 2160
AVVAVEEHIV SVSRDGTLKV WDHQGVELTS IPAHSGPISQ CAAALEPRPG GQPGSELLVV 2220
TVGLDGATKL WHPLLVCQIR TLQGHSGPVT AAAASEASGL LLTSDDSSVQ LWQIPKEADD 2280
SYKPRSSVAI TAVAWAPDGS MVVSGNEAGE LTLWQQAKAV ATAQAPGRVS HLIWYSANSF 2340
FVLSANENVS EWQVGLRKGS TSTSSSLHLK RVLQEDWGVL TGLGLAPDGQ SLILMKEDVE 2400
LLEMKPGSIP SSICRRYGVH SSILCTSKEY GLFYLQQGDS GLLSILEQKE SGEFEEILDF 2460
NLNLNNPNGS PVSITQAKPE SESSLLCATS DGMLWNLSEC TSEGEWIVDN IWQKKAKKPK 2520
TQTLETELSP HSELDFSIDC WIDPTNLKAQ QCKKIHLGSV TALHVLPGLL VTASKDRDVK 2580
LWERPSMQLL GLFRCEGPVS CLEPWMEPSS PLQLAVGDTQ GNLYFLSWE 2629 |
Gene Ontology | |
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