UniProt Accession

 PMM2_MOUSE; Q9Z2M7 

Genbank Protein ID

 AF043514; BC046325 

Genbank Nucleotide ID

 AAD02276.1; AAH46325.1 

Protein Name

 Phosphomannomutase 2 

Protein Synonyms/Alias

 PMM 2 

Gene Name

 Pmm2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
30	EMDGFLQKLRQKTKI	ubiquitination	[1]
73	ENGLVAYKDGKLLCK	acetylation	[2]
145	IEFYELDKKEHIRQK	acetylation	[2, 3, 4, 5]
198	HLEHAGYKTIYFFGD	acetylation	[6]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [6] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions (By similarity). 

Sequence Annotation

 ACT_SITE 8 8 Nucleophile (By similarity).
 ACT_SITE 10 10 By similarity.
 ACT_SITE 43 43 By similarity.
 ACT_SITE 185 185 By similarity.
 BINDING 17 17 Substrate (By similarity).
 BINDING 119 119 Substrate (By similarity).
 BINDING 130 130 Substrate (By similarity).
 BINDING 137 137 Substrate (By similarity).
 BINDING 175 175 Substrate (By similarity).
 BINDING 177 177 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Isomerase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 242 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0004615; F:phosphomannomutase activity; IEA:EC.
 GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0019307; P:mannose biosynthetic process; IEA:InterPro. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006379; HAD-SF_hydro_IIB.
 IPR005002; PMM. 

Pfam

 PF03332; PMM 

SMART

  

PROSITE

  

PRINTS