UniProt Accession

 ARP5L_HUMAN; Q9BPX5; Q7Z523 

Genbank Protein ID

 AF087842; AL354928; BC000018; BC000798; BC002418 

Genbank Nucleotide ID

 AAP97155.1; CAI39641.1; AAH00018.1; AAH00798.1; AAH02418.1 

Protein Name

 Actin-related protein 2/3 complex subunit 5-like protein 

Protein Synonyms/Alias

 Arp2/3 complex 16 kDa subunit 2; ARC16-2 

Gene Name

 ARPC5L 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	IDEFDENKFVDEQEE	ubiquitination	[1]
69	RNSPVNTKNQAVKER	ubiquitination	[1, 2]
83	RAQGVVLKVLTNFKS	ubiquitination	[2]
89	LKVLTNFKSSEIEQA	ubiquitination	[1, 2, 3, 4, 5]
110	NGVDLLMKYIYKGFE	ubiquitination	[1, 2]
114	LLMKYIYKGFEKPTE	ubiquitination	[2]
118	YIYKGFEKPTENSSA	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. 

Sequence Annotation

 MOD_RES 64 64 Phosphoserine.  

Keyword

 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 153 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro. 

Interpro

 IPR006789; ARP2/3_p16_Arc. 

Pfam

 PF04699; P16-Arc 

SMART

  

PROSITE

  

PRINTS