UniProt Accession

 LICH_HUMAN; P38571; B2RBH5; D3DR29; Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0 

Genbank Protein ID

 M74775; U04285; U04286; U04287; U04288; U04290; U04291; U04292; U04293; X76488; Z31690; U08464; AK314665; AK222760; AL353751; AL353146; AL513533; AL353751; AL513533; AL353146; AL353751; AL513533; AL513533; AL353146; AL353751; AL513533; AL353751; CH471066; CH471066; CH471066; BC012287 

Genbank Nucleotide ID

 AAA59519.1; AAB60327.1; AAB60327.1; AAB60327.1; AAB60327.1; AAB60327.1; AAB60327.1; AAB60327.1; AAB60327.1; CAA54026.1; CAA83495.1; AAB60328.1; BAG37222.1; BAD96480.1; CAI12234.1; CAI12234.1; CAI12234.1; CAI12236.1; CAI12236.1; CAI12380.1; CAI12380.1; CAI12380.1; CAI13515.1; CAI13515.1; CAI13515.1; CAI13516.1; CAI13516.1; EAW50140.1; EAW50141.1; EAW50142.1; AAH12287.1 

Protein Name

 Lysosomal acid lipase/cholesteryl ester hydrolase 

Protein Synonyms/Alias

 Acid cholesteryl ester hydrolase; LAL; Cholesteryl esterase; Lipase A; Sterol esterase 

Gene Name

 LIPA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
304	SQAVKFQKFQAFDWG	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. 

Sequence Annotation

 ACT_SITE 174 174 Charge relay system (By similarity).
 ACT_SITE 374 374 Charge relay system (By similarity).
 CARBOHYD 36 36 N-linked (GlcNAc...) (Potential).
 CARBOHYD 72 72 N-linked (GlcNAc...) (Potential).
 CARBOHYD 101 101 N-linked (GlcNAc...) (Potential).
 CARBOHYD 161 161 N-linked (GlcNAc...).
 CARBOHYD 273 273 N-linked (GlcNAc...) (Potential).
 CARBOHYD 321 321 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism; Lysosome; Polymorphism; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 399 AA 

Protein Sequence

Gene Ontology

 GO:0005764; C:lysosome; TAS:ProtInc.
 GO:0016298; F:lipase activity; IDA:UniProtKB.
 GO:0004771; F:sterol esterase activity; IDA:UniProtKB.
 GO:0000902; P:cell morphogenesis; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0001816; P:cytokine production; IEA:Compara.
 GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0048771; P:tissue remodeling; IEA:Compara. 

Interpro

 IPR000073; AB_hydrolase_1.
 IPR006693; AB_hydrolase_lipase.
 IPR025483; Lipase_euk. 

Pfam

 PF04083; Abhydro_lipase
 PF00561; Abhydrolase_1 

SMART

  

PROSITE

 PS00120; LIPASE_SER 

PRINTS