| Tag | Content |
|---|
| CPLM ID | CPLM-000172 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium/bile acid cotransporter |
Protein Synonyms/Alias | Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1 |
Gene Name | Slc10a1 |
Gene Synonyms/Alias | Ntcp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 151 | GIYDGDLKDKVPYKG | ubiquitination | [1] | | 322 | DQTKITYKAAATEDA | ubiquitination | [1] | | 336 | ATPAALEKGTHNGNN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. |
Sequence Annotation | CARBOHYD 5 5 N-linked (GlcNAc...) (Potential).
CARBOHYD 11 11 N-linked (GlcNAc...) (Potential).
CARBOHYD 103 103 N-linked (GlcNAc...) (Potential).
CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
CARBOHYD 271 271 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 362 AA |
Protein Sequence | MEAHNVSAPF NFSLPPGFGH RATDTALSVI LVVMLLLIML SLGCTMEFSK IKAHFWKPKG 60
VIIAIVAQYG IMPLSAFLLG KVFHLTSIEA LAILICGCSP GGNLSNLFTL AMKGDMNLSI 120
VMTTCSSFTA LGMMPLLLYI YSKGIYDGDL KDKVPYKGIM LSLVMVLIPC AIGIFLKSKR 180
PHYVPYVLKA GMIITFSLSV AVTVLSVINV GNSIMFVMTP HLLATSSLMP FTGFLMGYIL 240
SALFRLNPSC RRTISMETGF QNVQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLF 300
IIIFRCYLKI KPQKDQTKIT YKAAATEDAT PAALEKGTHN GNNPPTQPGL SPNGLNSGQM 360
AN 362 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; IDA:MGI. GO:0008508; F:bile acid:sodium symporter activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |