CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017551
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kelch repeat and BTB domain-containing protein 3 
Protein Synonyms/Alias
 BTB and kelch domain-containing protein 3 
Gene Name
 KBTBD3 
Gene Synonyms/Alias
 BKLHD3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
415TRGSRDIKSLLDVESubiquitination[1]
428ESYNPLSKEWISVSPubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 DOMAIN 48 115 BTB.
 DOMAIN 150 252 BACK.
 REPEAT 291 337 Kelch 1.
 REPEAT 339 399 Kelch 2.
 REPEAT 400 450 Kelch 3.
 REPEAT 452 502 Kelch 4.
 REPEAT 548 595 Kelch 5.  
Keyword
 Complete proteome; Kelch repeat; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 608 AA 
Protein Sequence
MDNSYAFNQR STCNGIPSEK KNNFLVSEDH GQKILSVLQN FREQNVFYDF KIIMKDEIIP 60
CHRCVLAACS DFFRAMFEVN MKERDDGSVT ITNLSSKAVK AFLDYAYTGK TKITDDNVEM 120
FFQLSSFLQV SFLSKACSDF LIKSINLVNC LQLLSISDSY GSTSLFDHAL HFVQHHFSLL 180
FKSSDFLEMN FGVLQKCLES DELNVPEEEM VLKVVLSWTK HNLESRQKYL PHLIEKVRLH 240
QLSEETLQDC LFNEESLLKS TNCFDIIMDA IKCVQGSGGL FPDARPSTTE KYIFIHKTEE 300
NGENQYTFCY NIKSDSWKIL PQSHLIDLPG SSLSSYGEKI FLTGGCKGKC CRTVRLHIAE 360
SYHDATDQTW CYCPVKNDFF LVSTMKTPRT MHTSVMALDR LFVIGGKTRG SRDIKSLLDV 420
ESYNPLSKEW ISVSPLPRGI YYPEASTCQN VIYVLGSEVE ITDAFNPSLD CFFKYNATTD 480
QWSELVAEFG QFFHATLIKA VPVNCTLYIC DLSTYKVYSF CPDTCVWKGE GSFECAGFNA 540
GAIGIEDKIY ILGGDYAPDE ITDEVQVYHS NRSEWEEVSP MPRALTEFYC QVIQFNKYRD 600
PWFSNLCA 608 
Gene Ontology
  
Interpro
 IPR011705; BACK.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR017096; Kelch-like_gigaxonin.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 
Pfam
 PF07707; BACK
 PF00651; BTB
 PF01344; Kelch_1 
SMART
 SM00875; BACK
 SM00225; BTB
 SM00612; Kelch 
PROSITE
 PS50097; BTB 
PRINTS