| Tag | Content |
|---|
| CPLM ID | CPLM-008896 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Origin recognition complex subunit 1 |
Protein Synonyms/Alias | Origin recognition complex 120 kDa subunit |
Gene Name | ORC1 |
Gene Synonyms/Alias | YML065W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 719 | RAAEIAEKHYMAKHG | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication. |
Sequence Annotation | DOMAIN 48 188 BAH.
NP_BIND 479 486 ATP (Potential).
NP_BIND 726 733 ATP (Potential).
MOD_RES 237 237 Phosphoserine. |
Keyword | 3D-structure; ATP-binding; Complete proteome; Direct protein sequencing; DNA replication; DNA-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 914 AA |
Protein Sequence | MAKTLKDLQG WEIITTDEQG NIIDGGQKRL RRRGAKTEHY LKRSSDGIKL GRGDSVVMHN 60
EAAGTYSVYM IQELRLNTLN NVVELWALTY LRWFEVNPLA HYRQFNPDAN ILNRPLNYYN 120
KLFSETANKN ELYLTAELAE LQLFNFIRVA NVMDGSKWEV LKGNVDPERD FTVRYICEPT 180
GEKFVDINIE DVKAYIKKVE PREAQEYLKD LTLPSKKKEI KRGPQKKDKA TQTAQISDAE 240
TRATDITDNE DGNEDESSDY ESPSDIDVSE DMDSGEISAD ELEEEEDEEE DEDEEEKEAR 300
HTNSPRKRGR KIKLGKDDID ASVQPPPKKR GRKPKDPSKP RQMLLISSCR ANNTPVIRKF 360
TKKNVARAKK KYTPFSKRFK SIAAIPDLTS LPEFYGNSSE LMASRFENKL KTTQKHQIVE 420
TIFSKVKKQL NSSYVKEEIL KSANFQDYLP ARENEFASIY LSAYSAIESD SATTIYVAGT 480
PGVGKTLTVR EVVKELLSSS AQREIPDFLY VEINGLKMVK PTDCYETLWN KVSGERLTWA 540
ASMESLEFYF KRVPKNKKKT IVVLLDELDA MVTKSQDIMY NFFNWTTYEN AKLIVIAVAN 600
TMDLPERQLG NKITSRIGFT RIMFTGYTHE ELKNIIDLRL KGLNDSFFYV DTKTGNAILI 660
DAAGNDTTVK QTLPEDVRKV RLRMSADAIE IASRKVASVS GDARRALKVC KRAAEIAEKH 720
YMAKHGYGYD GKTVIEDENE EQIYDDEDKD LIESNKAKDD NDDDDDNDGV QTVHITHVMK 780
ALNETLNSHV ITFMTRLSFT AKLFIYALLN LMKKNGSQEQ ELGDIVDEIK LLIEVNGSNK 840
FVMEIAKTLF QQGSDNISEQ LRIISWDFVL NQLLDAGILF KQTMKNDRIC CVKLNISVEE 900
AKRAMNEDET LRNL 914 |
Gene Ontology | GO:0031261; C:DNA replication preinitiation complex; IDA:SGD. GO:0005664; C:nuclear origin of replication recognition complex; IDA:SGD. GO:0005656; C:pre-replicative complex; IDA:SGD. GO:0005524; F:ATP binding; IDA:SGD. GO:0016887; F:ATPase activity; IMP:SGD. GO:0003682; F:chromatin binding; IDA:SGD. GO:0003688; F:DNA replication origin binding; IDA:SGD. GO:0030466; P:chromatin silencing at silent mating-type cassette; IDA:SGD. GO:0006270; P:DNA replication initiation; IMP:SGD. GO:0006267; P:pre-replicative complex assembly; IDA:SGD. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |