CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004202
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 2, facilitated glucose transporter member 4 
Protein Synonyms/Alias
 GT2; Glucose transporter type 4, insulin-responsive; GLUT-4 
Gene Name
 Slc2a4 
Gene Synonyms/Alias
 Glut-4; Glut4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
261SDALAELKDEKRKLEubiquitination[1]
495SLLEQEVKPSTELEYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Insulin-regulated facilitative glucose transporter. 
Sequence Annotation
 REGION 7 13 SRFBP1-binding (By similarity).
 REGION 294 296 Defines substrate specificity (By
 MOTIF 489 490 Dileucine internalization motif
 MOD_RES 274 274 Phosphoserine; by SGK1 (By similarity).
 MOD_RES 488 488 Phosphoserine.
 CARBOHYD 57 57 N-linked (GlcNAc...).  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Diabetes mellitus; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Sugar transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 509 AA 
Protein Sequence
MPSGFQQIGS DDGEPPRQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK VIEQSYNATW 60
LGRQGPGGPD SIPQGTLTTL WALSVAIFSV GGMISSFLIG IISQWLGRKR AMLANNVLAV 120
LGGALMGLAN AAASYEILIL GRFLIGAYSG LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI 180
VIGILVAQVL GLESMLGTAT LWPLLLALTV LPALLQLILL PFCPESPRYL YIIRNLEGPA 240
RKSLKRLTGW ADVSDALAEL KDEKRKLERE RPMSLLQLLG SRTHRQPLII AVVLQLSQQL 300
SGINAVFYYS TSIFESAGVG QPAYATIGAG VVNTVFTLVS VLLVERAGRR TLHLLGLAGM 360
CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG PIPWFIVAEL FSQGPRPAAM 420
AVAGFSNWTC NFIVGMGFQY VADAMGPYVF LLFAVLLLGF FIFTFLKVPE TRGRTFDQIS 480
AAFRRTPSLL EQEVKPSTEL EYLGPDEND 509 
Gene Ontology
 GO:0005905; C:coated pit; IEA:Compara.
 GO:0030659; C:cytoplasmic vesicle membrane; IDA:MGI.
 GO:0005768; C:endosome; IDA:MGI.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0070062; C:extracellular vesicular exosome; IDA:MGI.
 GO:0032593; C:insulin-responsive compartment; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IDA:MGI.
 GO:0005771; C:multivesicular body; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0030140; C:trans-Golgi network transport vesicle; IDA:MGI.
 GO:0055056; F:D-glucose transmembrane transporter activity; IEA:Compara.
 GO:0005360; F:insulin-responsive hydrogen:glucose symporter activity; TAS:MGI.
 GO:0010021; P:amylopectin biosynthetic process; IDA:MGI.
 GO:0050873; P:brown fat cell differentiation; IDA:MGI.
 GO:0032869; P:cellular response to insulin stimulus; IDA:UniProtKB.
 GO:0071470; P:cellular response to osmotic stress; IDA:MGI.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara. 
Interpro
 IPR002441; Glc_transpt_4.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR005828; Sub_transporter.
 IPR003663; Sugar/inositol_transpt.
 IPR005829; Sugar_transporter_CS. 
Pfam
 PF00083; Sugar_tr 
SMART
  
PROSITE
 PS50850; MFS
 PS00216; SUGAR_TRANSPORT_1
 PS00217; SUGAR_TRANSPORT_2 
PRINTS
 PR01193; GLUCTRSPORT4.
 PR00171; SUGRTRNSPORT.